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Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells

  1. Author:
    Hurwitz, A. A.
    Watkins, S. K.

  2. Author Address

    [Hurwitz, Arthur A.; Watkins, Stephanie K.] NCI, Tumor Immun & Tolerance Sect, Mol Immunoregulat Lab, Canc & Inflammat Program, Frederick, MD 21702 USA.;Hurwitz, AA (reprint author), NCI, Tumor Immun & Tolerance Sect, Mol Immunoregulat Lab, Canc & Inflammat Program, 211 Bldg 567,1050 Boyles St, Frederick, MD 21702 USA;hurwitza@mail.nih.gov
    1. Year: 2012
    2. Date: Feb
  2. Journal: Cancer Immunology Immunotherapy
    1. 61
    2. 2
    3. Pages: 289-293
  4. Type of Article: Review
  5. ISSN: 0340-7004
  1. Abstract:

    Immune suppression remains a consistent obstacle to successful anti-tumor immune responses. As tumors develop, they create a microenvironment that not only supports tumor growth and metastasis but also reduces potential adaptive immunity to tumor antigens. Among the many components of this tumor microenvironment is a population of dendritic cells which exert profound immune suppressive effects on T cells. In this review, we discuss our recent findings related to these tumor-associated dendritic cells and how targeting them may serve to generate more durable anti-tumor immune responses.

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External Sources

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  2. DOI: 10.1007/s00262-011-1181-5
  3. View record in Web of Science®
  4. WOS: 000300662200016

Library Notes

  1. Fiscal Year: FY2011-2012
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