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Functional Evidence For a Nasopharyngeal Carcinoma Tumor Suppressor Gene That Maps At Chromosome 3p21.3

  1. Author:
    Cheng, Y.
    Poulos, N. E.
    Lung, M. L.
    Hampton, G.
    Ou, B. X.
    Lerman, M. I.
    Stanbridge, E. J.
    1. Year: 1998
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 95
    2. 6
    3. Pages: 3042-3047
  4. Type of Article: Article
  1. Abstract:

    Nasopharyngeal carcinoma is a malignancy that is prevalent among populations from Southeast Asia. Epidemiological studies indicate that genetic predisposition, Epstein-Barr virus, and environmental conditions may play a role in determining incidence. Molecular studies have implicated a tumor suppressor gene(s) on the short arm of chromosome 3. In this study we provide functional evidence, via monochromosome transfer, for a tumor suppressor gene(s) activity in chromosome 3p21.3. [References: 46]

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