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Emerging Viruses in the Felidae: Shifting Paradigms

  1. Author:
    O'Brien, S. J.
    Troyer, J. L.
    Brown, M. A.
    Johnson, W. E.
    Antunes, A.
    Roelke, M. E.
    Pecon-Slattery, J.

  2. Author Address

    [O'Brien, Stephen J.; Johnson, Warren E.; Pecon-Slattery, Jill] NCI, Lab Genom Divers, Frederick, MD 21702 USA. [Troyer, Jennifer L.; Roelke, Melody E.] NCI, SAIC Frederick Inc, Frederick, MD 21702 USA. [Brown, Meredith A.] Banfield Pet Hosp, Portland, OR 97213 USA. [Antunes, Agostinho] Univ Porto, CIMAR CIIMAR, P-4050123 Oporto, Portugal.;O'Brien, SJ (reprint author), St Petersburg State Univ, Theodosius Dobzhansky Ctr Genome Bioinformat, St Petersburg 190000, Russia;lgdchief@gmail.com troyerj@mail.nih.gov Meredith.Brown@banfield.net warjohns@mail.nih.gov aantunes@ciimar.up.pt Melody.Roelke-Parker@nih.gov slatterj@mail.nih.gov
    1. Year: 2012
    2. Date: Feb
  2. Journal: Viruses-Basel
    1. 4
    2. 2
    3. Pages: 236-257
  4. Type of Article: Review
  5. ISSN: 1999-4915
  1. Abstract:

    The domestic cat is afflicted with multiple viruses that serve as powerful models for human disease including cancers, SARS and HIV/AIDS. Cat viruses that cause these diseases have been studied for decades revealing detailed insight concerning transmission, virulence, origins and pathogenesis. Here we review recent genetic advances that have questioned traditional wisdom regarding the origins of virulent Feline infectious peritonitis (FIP) diseases, the pathogenic potential of Feline Immunodeficiency Virus (FIV) in wild non-domestic Felidae species, and the restriction of Feline Leukemia Virus (FeLV) mediated immune impairment to domestic cats rather than other Felidae species. The most recent interpretations indicate important new evolutionary conclusions implicating these deadly infectious agents in domestic and non-domestic felids.

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External Sources

  1. View Full Text
  2. DOI: 10.3390/v4020236
  3. View record in Web of Science®
  4. WOS: 000300720900003

Library Notes

  1. Fiscal Year: FY2011-2012
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