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Characterization of two mouse models of metastatic pheochromocytoma using bioluminescence imaging

  1. Author:
    Giubellino, A.
    Woldemichael, G. M.
    Sourbier, C.
    Lizak, M. J.
    Powers, J. F.
    Tischler, A. S.
    Pacak, K.

  2. Author Address

    [Giubellino, Alessio; Pacak, Karel] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA. [Woldemichael, Girma M.] NCI, Mol Targets Lab, SAIC Frederick Inc, NIH, Frederick, MD 21702 USA. [Sourbier, Carole] NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA. [Lizak, Martin J.] NINDS, Mouse Imaging Facil, NIH, Bethesda, MD 20892 USA. [Powers, James F.; Tischler, Arthur S.] Tufts Med Ctr, Dept Pathol, Boston, MA 02111 USA.;Giubellino, A (reprint author), NICHD, Program Reprod & Adult Endocrinol, NIH, Bldg 10 CRC,1E-3140,10 Ctr Dr, Bethesda, MD 20892 USA;giubella@mail.nih.gov
    1. Year: 2012
    2. Date: Mar
  2. Journal: Cancer Letters
    1. 316
    2. 1
    3. Pages: 46-52
  4. Type of Article: Article
  5. ISSN: 0304-3835
  1. Abstract:

    Pheochromocytoma is the most common tumor of the adrenal medulla in adults. The lack of sensitive animal models of pheochromocytoma has hindered the study of this tumor and in vivo evaluation of antitumor agents. In this study we generated two sensitive luciferase models using bioluminescent pheochromocytoma cells: an experimental metastasis model to monitor tumor spreading and a subcutaneous model to monitor tumor growth and spontaneous metastasis. These models offer a platform for sensitive, non-invasive and real-time monitoring of pheochromocytoma primary growth and metastatic burden to follow the course of tumor progression and for testing relevant antitumor treatments in metastatic pheochromocytoma. Published by Elsevier Ireland Ltd.

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External Sources

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  2. DOI: 10.1016/j.canlet.2011.10.019
  3. View record in Web of Science®
  4. WOS: 000299712400007

Library Notes

  1. Fiscal Year: FY2011-2012
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