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Mice lacking Wnt2b are viable and display a postnatal olfactory bulb phenotype

  1. Author:
    Tsukiyama, T.
    Yamaguchi, T. P.

  2. Author Address

    [Tsukiyama, Tadasuke] Hokkaido Univ, Dept Biochem, Grad Sch Med, Kita Ku, Sapporo, Hokkaido 0608638, Japan. [Tsukiyama, Tadasuke; Yamaguchi, Terry P.] NCI, Ctr Canc Res, Canc & Dev Biol Lab, Cell Signaling Vertebrate Dev Sect,NIH, Frederick, MD 21702 USA.;Tsukiyama, T (reprint author), Hokkaido Univ, Dept Biochem, Grad Sch Med, Kita Ku, N15,W7, Sapporo, Hokkaido 0608638, Japan;tsukit@med.hokudai.ac.jp
    1. Year: 2012
    2. Date: Mar
  2. Journal: Neuroscience Letters
    1. 512
    2. 1
    3. Pages: 48-52
  4. Type of Article: Article
  5. ISSN: 0304-3940
  1. Abstract:

    Wnts are secreted glycoproteins that play important roles in embryonic development. Wnt2b is transiently expressed in the primitive streak (PS) during gastrulation and in several organs during organogenesis. To determine the biological function of Wnt2b during mouse development, we established a conditional null allele of Wnt2b. Mice lacking Wnt2b were viable, fertile, and displayed a normal life span, however, the olfactory bulb in adult Wnt2b mutant mice was significantly reduced in length. Our results suggest that Wnt2b primarily plays a supportive role in gastrulation and organogenesis, functioning redundantly with canonical Wnts, such as Wnt2, in numerous tissues. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.neulet.2012.01.062
  3. View record in Web of Science®
  4. WOS: 000302512500010

Library Notes

  1. Fiscal Year: FY2011-2012
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