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Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway

  1. Author:
    Zhu, J. J.
    Nguyen, M. T.
    Nakamura, E.
    Yang, J. M.
    Mackem, S.

  2. Author Address

    [Zhu, Jianjian; Minh-Thanh Nguyen; Nakamura, Eiichiro; Yang, Junming; Mackem, Susan] NCI, Ctr Canc Res, Canc & Dev Biol Lab, Ft Detrick, MD 21702 USA. [Minh-Thanh Nguyen] Univ Cincinnati, Dept Ophthalmol, Cincinnati, OH 45221 USA. [Nakamura, Eiichiro] Univ Occupat & Environm Hlth, Dept Orthoped Surg, Kitakyushu Fukuoka 8078555, Japan.;Mackem, S (reprint author), NCI, Ctr Canc Res, Canc & Dev Biol Lab, 1050 Boyles St,Bldg 539,Room 121A, Ft Detrick, MD 21702 USA;smack@helix.nih.gov
    1. Year: 2012
    2. Date: Feb
  2. Journal: Genesis
    1. 50
    2. 2
    3. Pages: 102-111
  4. Type of Article: Article
  5. ISSN: 1526-954X
  1. Abstract:

    Cre-mediated apoptosis has been observed in many contexts in mice expressing Cre-recombinase and can confound the analysis of genetically engineered conditional mutant or transgenic alleles. Several mechanisms have been proposed to explain this phenomenon. We find that the degree of apoptosis induced correlates roughly with the copy number of loxP sites present in the genome and that some level of increased apoptosis accompanies the presence of even only a few loxP sites, as occurs in conditional floxed alleles. Cre-induced apoptosis in this context is completely p53-dependent, suggesting that the apoptosis is stimulated by p53 activation in response to DNA damage incurred during the process of Cre-mediated recombination. genesis 50:102111, 2012. (C) 2011 Wiley Periodicals, Inc.

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External Sources

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  2. DOI: 10.1002/dvg.20799
  3. View record in Web of Science®
  4. WOS: 000299835500003

Library Notes

  1. Fiscal Year: FY2011-2012
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