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Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25

  1. Author:
    Cerretti, D. P.
    Poindexter, K.
    Castner, B. J.
    Means, G.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    Black, R. A.
    Nelson, N.

  2. Author Address

    Cerretti DP Immunex Corp 51 Univ St Seattle, WA 98101 USA Immunex Corp Seattle, WA 98101 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mammalian Genet Lab Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Cytokine
    1. 11
    2. 8
    3. Pages: 541-551
  4. Type of Article: Article
  1. Abstract:

    Numerous proteins are cleaved or "shed" from their membrane-bound form. One such protein, tumour necrosis factor alpha (TNF-alpha), is synthesized as a type 2 transmembrane protein. Recently, a human protease responsible for this shedding, the TNF-alpha converting enzyme (TACE/ADAM17), was isolated. TACE/ADAM17 is a member of the adamalysin class of zinc-binding metalloproteases or ADAM (a disintegrin and metalloprotease). We report the isolation and characterization of the mouse TACE/ADAM17 cDNA and gene, Mouse TACE/ADAM17 has a 92% amino-acid identity with the human protein and was ubiquitously expressed. A recombinant form of the protease is found to cleave a peptide representing the cleavage site of precursor mouse TNF-alpha.An alternatively spliced form of mouse TACE/ADAM17 was found that would produce a soluble protein. The gene for TACE/ADAM17 is approximately 50 kb and contains 19 exons, Chromosomal mapping places TACE/ADAM17 on mouse chromosome 12 and human chromosome 2p25. (C) 1999 Academic Press. [References: 53]

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