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Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, AND DPB1) loci in 26 human ethnic groups

  1. Author:
    Chen, J. J.
    Hollenbach, J. A.
    Trachtenberg, E. A.
    Just, J. J.
    Carrington, M.
    Ronningen, K. S.
    Begovich, A.
    King, M. C.
    McWeeney, S.
    Mack, S. J.
    Erlich, H. A.
    Thomson, G.

  2. Author Address

    Chen JJ St Louis Univ, Sch Publ Hlth 3663 Lindell Blvd St Louis, MO 63108 USA St Louis Univ, Sch Publ Hlth St Louis, MO 63108 USA Univ Calif Berkeley, Dept Integrat Biol Berkeley, CA 94720 USA Childrens Hosp, Oakland Res Inst Oakland, CA 94609 USA Millenium Pharmaceut, Dept Human Genet Cambridge, MA USA NCI, Frederick Canc Res & Dev Ctr Frederick, MD USA Natl Inst Publ Hlth, Epidemiol Sect Oslo Norway Roche Mol Syst, Dept Human Genet Alameda, CA USA Univ Washington, Dept Genet Seattle, WA 98195 USA Univ Washington, Dept Med Seattle, WA 98195 USA
    1. Year: 1999
  2. Journal: Tissue Antigens
    1. 54
    2. 6
    3. Pages: 533-542
  4. Type of Article: Article
  1. Abstract:

    Testing the fit of population data to Hardy-Weinberg proportions is crucial in the validation of many current approaches in population genetic studies. In this paper, we tested fit to Hardy-Weinberg proportions using exact approaches for both the overall and individual heterozygote genotype data of four HLA Class II loci: DRB1, DQA1, DQB1, and DPB1, from 26 human populations. Eighty of 99 overall tests fit the Hardy-Weinberg expectation (73% for DRB1, 89% for DQA1, 81% for DQB1 and 81% for DPB1). Deviations from Hardy-Weinberg proportions were both locus and group specific. Although we could not rule out other mechanisms at work, the individual test results indicated that the departure was possibly partly due to recent admixture. Evidence for selection and other sources of deviation are also discussed. [References: 24]

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