Skip NavigationSkip to Content
Return Return to Search Results

Salicylihalamides a and B, Novel Cytotoxic Macrolides From the Marine Sponge Haliclona Sp

  1. Author:
    Erickson, K. L.
    Beutler, J. A.
    Cardellina, J. H.
    Boyd, M. R.

  2. Author Address

    Boyd MR NCI FREDERICK CANC RES & DEV CTR LAB DRUG DISCOVERY RES & DEV DEV THERAPEUT PROGRAM FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR LAB DRUG DISCOVERY RES & DEV DEV THERAPEUT PROGRAM FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Journal of Organic Chemistry
    1. 62
    2. 23
    3. Pages: 8188-8192
  4. Type of Article: Article
  1. Abstract:

    Two novel, highly potent, cytotoxic macrolides, salicylihalamides A (1) and B (2), were isolated from the sponge Haliclona sp. This new macrolide class incorporates salicylic acid, a 12-membered lactone ring, and an enamide side chain. COMPARE pattern-recognition analyses of the NCI 60-cell mean graph screening profiles of 1 did not reveal any significant correlations to the profiles of known antitumor compounds in the NCI's ''standard agent database'', thus supporting the conclusion that the salicylihalamides represent a potentially important new class for antitumor lead optimization and in vivo investigations. [References: 29]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel