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Discovery and development of antineoplastic agents from natural sources

  1. Author:
    Cragg, G. M.
    Newman, D. J.

  2. Author Address

    Cragg GM NCI, Frederick Canc Res & Dev Ctr, Nat Prod Branch,Dev Therapeut Program, Div Canc Treatment & Diag Fairview Ctr,POB B Frederick, MD 21701 USA NCI, Frederick Canc Res & Dev Ctr, Nat Prod Branch,Dev Therapeut Program, Div Canc Treatment & Diag Frederick, MD 21701 USA
    1. Year: 1999
  2. Journal: Cancer Investigation
    1. 17
    2. 2
    3. Pages: 153-163
  4. Type of Article: Article
  1. Abstract:

    Nature has provided many effective anticancer. agents in current use, such as the microbially derived drugs; dactinomycin, bleomycin ann doxorubicin; and the plant-derived drugs, vinblastine, irinotecan, topotecan, etoposide, and paclitaxel. The search for novel antitumor agents front natural sources continues through collaboration among scientists worldwide in the investigation of coral reefs, rainforests, and deep subsurface thermal vents for novel bioactive compounds. The potential for drug discovery is being further enhanced by recent advances in procedures for microbial cultivation and the extraction of nucleic acids from environmental samples, resulting in the identification of novel microbes that provide a vast untapped reservoir of generic and metabolic diversity. Manipulation of the biosynthetic pathways of microbial polyketides through genetic engineering permits the biosynthesis of bioactive polyketides not generated naturally. [References: 32]

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