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Isolation and Characterization of Novel Cytotoxic Saponins From Archidendron Ellipticum

  1. Author:
    Beutler, J. A.
    Kashman, Y.
    Pannell, L. K.
    Cardellina, J. H.
    Alexander, M. R. A.
    Balaschak, M. S.
    Prather, T. R.
    Shoemaker, R. H.
    Boyd, M. R.

  2. Author Address

    Boyd MR NCI LAB DRUG DISCOVERY RES & DEV DEV THERAPEUT PROGRAM DIV CANC BIOL DIAG & CTR FREDERICK, MD 21702 USA NCI LAB DRUG DISCOVERY RES & DEV DEV THERAPEUT PROGRAM DIV CANC BIOL DIAG & CTR FREDERICK, MD 21702 USA TEL AVIV UNIV DEPT CHEM IL-69978 TEL AVIV ISRAEL NIDDKD ANALYT CHEM LAB NIH BETHESDA, MD 20892 USA SCI APPLICAT INT CORP FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Bioorganic & Medicinal Chemistry
    1. 5
    2. 8
    3. Pages: 1509-1517
  4. Type of Article: Article
  1. Abstract:

    A series of new ester saponins, elliptosides A-J, has been isolated from the tropical plant Archidendron ellipticum (Leguminosae). These saponins were particularly cytotoxic to certain renal and melanoma cancer cell lines in the NCI's 60-cell line human tumor screen. The structures of elliptosides A, E, and F were elucidated by spectroscopic and chemical means. Elliptoside A showed in vivo antitumor activity against the LOX melanoma cell line. Published by Elsevier Science Ltd. [References: 32]

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