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Chromosomal mapping of five mouse G protein gamma subunits

  1. Author:
    Downes, G. B.
    Gilbert, D. J.
    Copeland, N. G.
    Gautam, N.
    Jenkins, N. A.

  2. Author Address

    Gautam N Washington Univ, Sch Med, Dept Anesthesiol St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Anesthesiol St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet St Louis, MO 63110 USA NCI, Frederick Canc Res & Dev Ctr, Mammalian Genet Lab Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Genomics
    1. 57
    2. 1
    3. Pages: 173-176
  4. Type of Article: Article
  1. Abstract:

    Heterotrimeric G proteins, composed of alpha, beta, and gamma subunits, transduce signals from transmembrane receptors to a wide range of intracellular effecters. The G protein gamma subunits, which play an indispensible role in this communication, constitute a large and diverse multigene family. Using an interspecific back cross panel, we have determined the mouse chromosomal locations of five gamma subunit genes: gamma 2, gamma 8, gamma 10, gamma 12, and gamma Cone. Combined with previous mapping studies, these data indicate that, with the possible exception of gamma 1 and gamma 11, the G protein gamma subunit genes are well dispersed within the mouse and human genomes. (C) 1999 Academic Press. [References: 27]

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