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Hiv-Inhibitory Natural Products .36. Michellamines D-F, New Hiv-Inhibitory Dimeric Naphthylisoquinoline Alkaloids, and Korupensamine E, a New Antimalarial Monomer, From Ancistrocladus Korupensis

  1. Author:
    Hallock, Y. F.
    Manfredi, K. P.
    Dai, J. R.
    Cardellina, J. H.
    Gulakowski, R. J.
    McMahon, J. B.
    Schaffer, M.
    Stahl, M.
    Gulden, K. P.
    Bringmann, G.
    Francois, G.
    Boyd, M. R.

  2. Author Address

    Bringmann G UNIV WURZBURG INST ORGAN CHEM AM HUBLAND D-97074 WURZBURG GERMANY UNIV WURZBURG INST ORGAN CHEM D-97074 WURZBURG GERMANY NCI DIAG & CTR DIV CANC TREATMENT LAB DRUG DISCOVERY RES & DEV DEV THERAPEUT PROGRAM FREDERICK, MD 21702 USA PRINS LEOPOLD INST TROP GENEESKUNDE B-2000 ANTWERP BELGIUM
    1. Year: 1997
  2. Journal: Journal of Natural Products
    1. 60
    2. 7
    3. Pages: 677-683
  4. Type of Article: Article
  1. Abstract:

    New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A-D. [References: 24]

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