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Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection

  1. Author:
    Houser, K. V.
    Gretebeck, L.
    Ying, T.
    Wang, Y.
    Vogel, L.
    Lamirande, E. W.
    Bock, K. W.
    Moore, I. N.
    Dimitrov, D. S.
    Subbarao, K.

  2. Author Address

    Laboratory of Infectious Diseases. Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, China. Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Frederick, Maryland. Comparative Medicine Branch, Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Disease, National Institutes of Health (NIH), Bethesda.
    1. Year: 2016
    2. Date: 15-May
    3. Epub Date: 3/5/2016
  2. Journal: The Journal of infectious diseases
    1. 213
    2. 10
    3. Pages: 1557-61
  4. Type of Article: Article
  5. ISSN: 0022-1899
  1. Abstract:

    With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40-9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336.

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External Sources

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  2. DOI: 10.1093/infdis/jiw080
  3. PMID: 26941283
  4. PMCID: PMC4837915

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