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Distribution of two HIV-1-resistant polymorphisms (SDF1-3 ' A and CCR2-641) in east Asian and world populations and its implication in AIDS epidemiology

  1. Author:
    Su, B.
    Jin, L.
    Hu, F.
    Xiao, J. H.
    Luo, J. C.
    Lu, D. R.
    Zhang, W. L.
    Chu, J. Y.
    Du, R. F.
    Geng, Z. C.
    Qiu, X. F.
    Xue, J. L.
    Tan, J. Z.
    O'Brien, S. J.
    Chakraborty, R.

  2. Author Address

    Jin L Univ Texas, Sch Publ Hlth, Ctr Human Genet 6901 Bertner Ave,POB 20334 Houston, TX 77225 USA Univ Texas, Sch Publ Hlth, Ctr Human Genet Houston, TX 77225 USA Fudan Univ, Inst Genet Shanghai Peoples R China Jingan Cent Hosp Shanghai Peoples R China Suzhou Med Sch Suzhou Jiangsu Peoples R China Chinese Acad Med Sci, Inst Med Biol Kunming Yunnan Peoples R China Chinese Acad Sci, Inst Genet Beijing Peoples R China NCI, Lab Genome Divers Frederick, MD 21701 USA
    1. Year: 1999
  2. Journal: American Journal of Human Genetics
    1. 65
    2. 4
    3. Pages: 1047-1053
  4. Type of Article: Article
  1. Abstract:

    Chemokine receptor CCR2 and stromal-derived factor (SDF-1) are involved in HIV infection and AIDS symptom onset. Recent cohort studies showed that point mutations in these two genes, CCR2-64I and SDF1-3'A, can delay AIDS onset greater than or equal to 16 years after seroconversions. The protective effect of CCR2-64I is dominant, whereas that of SDF1-3'A is recessive. SDF1-3'A homozygotes also showed possible protection against HIV-1 infection. In this study, we surveyed the frequency distributions of the two alleles at both loci in world populations, with emphasis on those in east Asia. The CCR2-64I frequencies do not vary significantly in the different continents, having a range of 0.1-0.2 in most populations. A decreasing dine of the CCR2-64I frequency from north to south was observed in east Asia. In contrast, the distribution of SDF1-3'A in world populations varies substantially, and the highest frequency was observed in Oceanian populations. Moreover, an increasing dine of the SDF1-3'A frequency from north to south was observed in east Asia. The relative hazard values were computed to evaluate the risk of AIDS onset on the basis of two-locus genotypes in the east Asian and world populations. [References: 18]

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