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Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

  1. Author:
    Suzuki, Airi
    Saito, Yohei
    Fukuyoshi, Shuichi
    Goto, Masuo
    Miyake, Katsunori
    Newman, Dave
    O'Keefe, Barry
    Lee, Kuo-Hsiung
    Nakagawa-Goto, Kyoko

  2. Author Address

    Kanazawa Univ, Coll Med Pharmaceut & Hlth Sci, Sch Pharmaceut Sci, Kanazawa, Ishikawa 9201192, Japan.Univ North Carolina Chapel Hill, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA.Tokyo Univ Pharm & Life Sci, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan.NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Frederick, MD 21702 USA.NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 USA.China Med Univ & Hosp, Chinese Med Res & Dev Ctr, 2 Yuh Der Rd, Taichung 40447, Taiwan.
    1. Year: 2017
    2. Date: Apr
  2. Journal: JOURNAL OF NATURAL PRODUCTS
  3. AMER CHEMICAL SOC,
    1. 80
    2. 4
    3. Pages: 1065-1072
  5. Type of Article: Article
  6. ISSN: 0163-3864
  1. Abstract:

    A bioactive CH3OH-CH2Cl2 (1:1) extract of the bark of Laetia corymbulosa provided' five new derodane diterpenes with an isozuelanin skeleton, designated as corymbulosins D-H (1-5), as well as the known- j corymbulosins B (6) and C (7), for which the relative configurations were not previously determined. The structures of 1-5 were characterized on the basis of 1D and 2D NMR spectroscopic and HRMS analysis. The absolute configurations of all isolated compounds 1-7 were verified through chemical methods, including modified Mosher esterifications or oxidation of the hydroxy group at C-2, ECD experiments, and spectroscopic data comparison. The isolated compounds were evaluated for antiproliferative activity against a small panel of human cancer cell lines.

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External Sources

  1. View Full Text
  2. DOI: 10.1021/acs.jnatprod.6b01151
  3. PMID: 28290698
  4. View record in Web of Science®
  5. WOS: 000400538800035

Library Notes

  1. Fiscal Year: FY2016-2017
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