Skip NavigationSkip to Content
Return Return to Search Results

A human genome map of comparative anchor tagged sequences

  1. Author:
    Chen, Z. Q.
    Lautenberger, J. A.
    Lyons, L. A.
    McKenzie, L.
    O'Brien, S. J.

  2. Author Address

    O'Brien SJ NCI, Lab Genom Divers Frederick, MD USA NCI, Lab Genom Divers Frederick, MD USA NCI, Intramural Res Support Program, SAIC Frederick Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Journal of Heredity
    1. 90
    2. 4
    3. Pages: 477-484
  4. Type of Article: Article
  1. Abstract:

    Effective comparative mapping inference utilizing developing gene maps of animal species requires the inclusion of anchored reference loci that are homologous to genes mapped in the more "gene-dense" mouse and human maps, Nominated anchor loci, termed comparative anchor tagged sequences (CATS), have been ordered in the mouse linkage map, but due to the dearth of common polymorphisms among human coding genes have not been well represented in human linkage maps. We present here an ordered framework map of 314 comparative anchor markers in humans based on mapping analysis in the Genebridge 4 panel of radiation hybrid cell lines, plus empirically optimized CATS PCR primers which detect these markers. The ordering of these homologous gene markers in human and mouse maps provides a framework for comparative gene mapping of representative mammalian species. [References: 30]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel