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Ly-49 receptor expression and functional analysis in multiple mouse strains

  1. Author:
    Ortaldo, J. R.
    Mason, A. T.
    Winkler-Pickett, R.
    Raziuddin, A.
    Murphy, W. J.
    Mason, L. H.

  2. Author Address

    Ortaldo JR NCI, Frederick Canc Res & Dev Ctr, Div Basic Sci, Expt Immunol Lab Bldg 560,Rm 31-93 Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Div Basic Sci, Expt Immunol Lab Frederick, MD 21702 USA SAIC Frederick, Intramural Res Support Program Frederick, MD USA
    1. Year: 1999
  2. Journal: Journal of Leukocyte Biology
    1. 66
    2. 3
    3. Pages: 512-520
  4. Type of Article: Article
  1. Abstract:

    We present data on the strain distribution and functional characteristics of the Ly-49 receptors A, C/I, D, and G2 on DX5(+) natural killer (NK) cells. We have examined tyrosine phosphorylation of the Ly-49 molecules, regulation of NIC cytotoxic functions, and in vivo marrow rejection capability. The Row cytometry results demonstrate a diverse and complex pattern of expression of the Ly-49 receptors in the 11 strains examined. The vast majority of NK cells express Ly-49s, although some NK1.1(+) CD3(+) cells also express these receptors, The results of our functional analysis indicate that H-2D(d) was able to inhibit the function of Ly-49G2(+) NIC cells, not only in B6 mice, but also by NK cells derived from several haplotypes, The examination of Ly-49 receptor tyrosine phosphorylation, which is a biochemical measure of inhibitory function, was consistently observed in the 11 mouse strains examined. In contrast, analysis of Ly-49D function suggests its expression appears to be more restricted and that H-2D(d) is an activating ligand for this receptor, In addition, the in vivo examination of both inhibitory (Ly-49G2) and activating (Ly-49D) receptors demonstrated regulatory roles of these class I binding receptors in marrow transplantation. [References: 31]

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