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Anticancer activity of Schiff base-Poloxamer P85 combination against kidney cancer

  1. Author:
    Dogan, Aysegul
    Demirci, Selami
    Telci, Dilek
    Canikyan, Serli
    Kongur, Merve
    Dede, Bülent
    Sahin, Fikrettin

  2. Author Address

    Genetics and Bioengineering Department, Faculty of Engineering, Yeditepe University, Kayisdagi, Istanbul, Turkey. aguldgn@gmail.com., National Cancer Institute, CDBL, NIH, Frederick, MD, USA. aguldgn@gmail.com., National Heart, Lung and Blood Institute (NHLBI), NIH, Bethesda, MD, USA., Onkim Stem Cell Technologies, Istanbul, Turkey., Acibadem Labcell, Stem Cell Laboratory and Umbilical Cord Blood Bank, Istanbul, Turkey., Department of Chemistry, Faculty of Sciences and Arts, S 252;leyman Demirel University, Isparta, Turkey.,
    1. Year: 2018
    2. Date: Feb
    3. Epub Date: 2017 12 29
  2. Journal: International urology and nephrology
    1. 50
    2. 2
    3. Pages: 247-255
  4. Type of Article: Article
  5. ISSN: 0301-1623
  1. Abstract:

    Renal cell carcinoma (RCC) accounts for approximately 80% of the primary renal cancers, and current treatment strategies are not sufficient to provide a certain solution. Since there are not many treatment options, interest in discovery of alternative drugs has increased. In the current study, anticancer activity of a novel heterodinuclear Cu(II)-Mn(II) complex (Schiff base-SB) in combination with poly(ethylene oxide) and poly(propylene oxide) block copolymer (pluronic) P85 was tested against RCC. Cell viability, apoptosis and gene expression analysis were conducted in vitro by using Renca cells. The results revealed that the SB-P85 combination decreased cell proliferation by increasing the apoptotic gene expressions and apoptosis. Renca-injected BALB/c mice were used to mimic early stage of RCC model. Treatment with SB-P85 combination suppressed tumor formation and growth compared to baseline. Overall, SB-P85 showed promising anticancer activity against RCC in vitro and in vivo.

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External Sources

  1. View Full Text
  2. DOI: 10.1007/s11255-017-1782-9
  3. PMID: 29288416
  4. View record in Web of Science®
  5. WOS: 000425010000009
  6. PII : 10.1007/s11255-017-1782-9

Library Notes

  1. Fiscal Year: FY2017-2018
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