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Telmisartan Does Not Improve Lymph Node or Adipose Tissue Fibrosis More Than Continued ART Alone

  1. Author:
    Utay, Netanya S
    Kitch, Douglas W
    Yeh, Eunice
    Fichtenbaum, Carl J
    Lederman, Michael M
    Estes, Jake
    Deleage, Claire
    Magyar, Clara
    Nelson, Scott D
    Klingman, Karen L
    Bastow, Barbara
    Luque, Amneris E
    McComsey, Grace A
    Douek, Daniel C
    Currier, Judith S
    Lake, Jordan E

  2. Author Address

    Department of Internal Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA., Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health; Boston, MA, USA., Department of Internal Medicine, University of Cincinnati, Cincinnati, OH USA., Center for AIDS Research, Department of Medicine, Case Western Reserve University, University Hospitals/Case Medical Center, Cleveland, OH, USA., AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA., Department of Pathology and Lab Medicine, University of California, Los Angeles, Los Angeles, CA, USA., HIV Research Branch, Therapeutics Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Social & Scientific Systems, Inc, Silver Spring, MD, USA., Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Case Western Reserve University School of Medicine, Cleveland, OH, USA., Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA., Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.,
    1. Year: 2018
    2. Date: Jun 1
    3. Epub Date: 2018 02 01
  2. Journal: The Journal of infectious diseases
    1. 217
    2. 11
    3. Pages: 1770-1781
  4. Type of Article: Article
  5. ISSN: 0022-1899
  1. Abstract:

    Fibrosis in lymph nodes may limit CD4+ T-cell recovery and lymph node and adipose tissue fibrosis may contribute to inflammation and comorbidities despite antiretroviral therapy (ART). We hypothesized that the angiotensin receptor blocker and PPAR-? agonist telmisartan would decrease lymph node or adipose tissue fibrosis in treated HIV-1 infection. In this 48-week, randomized-controlled trial, adults continued suppressive ART and received telmisartan or no drug. Collagen I, fibronectin, and phosphorylated SMAD3 (pSMAD3) deposition in lymph nodes, and collagen I, collagen VI, and fibronectin in adipose tissue, were quantified by immunohistochemistry at weeks 0 and 48. Two-sided rank-sum and signed-rank tests compared 48-week changes. Forty-four participants enrolled; 35 had paired adipose tissue; 29 had paired lymph nodes. Median overall % collagen I change was -2.6% (P=0.08) in lymph nodes and -1.3% (P=0.001) in adipose tissue, with no between-arm differences. In lymph nodes, pSMAD3 changed by -0.5% (P=0.04) overall, with no between-arm differences. Telmisartan attenuated fibronectin increases (P=0.06). In adipose tissue, collagen VI (-1.0%, P=0.001) and fibronectin (-2.4%, P< 0.001) levels decreased, with no between-arm differences. In adults with treated HIV-1 infection, lymph node and adipose tissue fibrosis decreased with continued ART alone, with no additional fibrosis reduction with telmisartan.

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External Sources

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  2. DOI: 10.1093/infdis/jiy064
  3. PMID: 29401318
  4. View record in Web of Science®
  5. WOS: 000434081100011
  6. PII : 4833221

Library Notes

  1. Fiscal Year: FY2017-2018
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