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Pharmacokinetics of dacarbazine (DTIC) in pregnancy

  1. Author:
    Kantrowitz-Gordon, Ira
    Hays, Karen
    Kayode, Olumide
    Kumar, Aditya R.
    Kaplan, Henry G.
    Reid, Joel M.
    Safgren, Stephanie L.
    Ames, Matthew M.
    Easterling, Thomas R.
    Hebert, Mary F.

  2. Author Address

    Univ Washington, Dept Family & Child Nursing, 1959 NE Pacific St, Seattle, WA 98195 USA.Univ Washington, Dept Pharm, 1959 NE Pacific St, Seattle, WA 98195 USA.Univ Washington, Dept Obstet & Gynecol, 1959 NE Pacific St, Seattle, WA 98195 USA.NCI, Ctr Canc Res, 8560 Progress Dr, Frederick, MD 21702 USA.Mayo Clin, Grad Sch Biomed Sci, Dept Mol Pharmacol & Expt Therapeut, 200 First St SW, Rochester, MN 55905 USA.Swedish Med Ctr, Swedish Canc Inst, 1221 Madison St 500, Seattle, WA 98104 USA.
    1. Year: 2018
    2. Date: Mar
  2. Journal: Cancer Chemotherapy and Pharmacology
  3. SPRINGER,
    1. 81
    2. 3
    3. Pages: 455-460
  5. Type of Article: Article
  6. ISSN: 0344-5704
  1. Abstract:

    The purpose of this report is to describe, for the first time, the pharmacokinetics of dacarbazine (DTIC) and its metabolites [5-[3-methyl-triazen-1-yl]-imidazole-4-carboxamide (MTIC), 5-[3-hydroxymethyl-3-methyl-triazen-1-yl]-imidazole-4-carboxamide (HMMTIC) and 5-aminoimidazole-4-carboxamide (AIC)] during pregnancy (n = 2) and postpartum (n = 1).

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External Sources

  1. View Full Text
  2. DOI: 10.1007/s00280-017-3511-6
  3. PMID: 29305638
  4. PMCID: PMC5828904
  5. View record in Web of Science®
  6. WOS: 000426060100003

Library Notes

  1. Fiscal Year: FY2017-2018
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