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Hemostatic and Absorbent PolyHIPE-Kaolin Composites for 3D Printable Wound Dressing Materials

  1. Author:
    Streifel, Benjamin C
    Lundin, Jeffrey G [ORCID]
    Sanders, Allix
    Gold, Karli A
    Wilems, Thomas S
    Williams, Sierra J
    Cosgriff-Hernandez, Elizabeth
    Wynne, James H

  2. Author Address

    Chemistry Division, Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC, 20375, USA., National Cancer Institute/National Institutes of Health, Frederick, MD, 21701, USA., Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.,
    1. Year: 2018
    2. Date: May
    3. Epub Date: 2018 04 17
  2. Journal: Macromolecular Bioscience
    1. 18
    2. 5
    3. Pages: e1700414
  4. Type of Article: Article
  5. Article Number: e1700414
  6. ISSN: 1616-5187
  1. Abstract:

    A novel hemostatic and absorbent wound dressing material compatible with 3D printing is developed to address deficiencies in current wound dressing protocol. The design involves an open celled, microporous hydrogel foam via a high internal phase emulsion (HIPE) template with biocompatible components and tunable hemostatic character by kaolin loading, the viscosity and cure kinetics of which are tailored for 3D printing applications. The use of nontoxic mineral oil organic phase results in cytocompatability with human dermal fibroblasts. Kaolin distribution is shown by X-ray diffraction and elemental dispersive spectroscopy to be exfoliated and dispersed in the hydrogel dressing. In addition to demonstrating high fluid absorption and noncytotoxicity of relevant cell lines, the high internal phase emulsion polymers (polyHIPEs) also match the hemostatic performance of commercial wound dressing materials. Furthermore, the polyHIPEs display the requisite rheological properties for 3D printing that result in the fabrication of a prototype dressing with hierarchical porosity and a large number of controllable form factors. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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External Sources

  1. View Full Text
  2. DOI: 10.1002/mabi.201700414
  3. PMID: 29665285
  4. View record in Web of Science®
  5. WOS: 000431504100005

Library Notes

  1. Fiscal Year: FY2017-2018
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