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Stellatolide H, a cytotoxic peptide lactone from a deep-sea sponge Discodermia sp.

  1. Author:
    Nakamukai, Shohei
    Takada, Kentaro
    Furihata, Kazuo
    Ise, Yuji
    Okada, Shigeru
    Morii, Yasuhiro
    Yamawaki, Nobuhiro
    Takatani, Tomohiro
    Arakawa, Osamu
    Gustafson, Kirk
    Matsunaga, Shigeki

  2. Author Address

    Univ Tokyo, Grad Sch Agr & Life Sci, Lab Aquat Nat Prod Chem, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138675, Japan.Univ Tokyo, Adv Instrumental Anal Unit, Grad Sch Agr & Life Sci, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138675, Japan.Nagoya Univ, Sugashima Marine Biol Lab, Toba, Mie 5170004, Japan.Nagasaki Univ, Grad Sch Fisheries Sci & Environm Studies, Nagasaki 8528521, Japan.NCI, Mol Targets Program, Ctr Canc Res, Frederick, MD 21702 USA.
    1. Year: 2018
    2. Date: Jun 27
  2. Journal: Tetrahedron Letters
  3. PERGAMON-ELSEVIER SCIENCE LTD,
    1. 59
    2. 26
    3. Pages: 2532-2536
  5. Type of Article: Article
  6. ISSN: 0040-4039
  1. Abstract:

    Stellatolide H (1) was isolated from a deep-sea sponge Discodermia sp. as the cytotoxic constituent. The planar structure of 1 was elucidated on the basis of the NMR spectroscopic and mass spectrometric data. The absolute configurations of the constituent amino acid residues were determined by the Marfey's method. Stellatolide H (1) is a peptide lactone of the callipeltin class with its N-terminus blocked by 3-hydroxy-6,8-dimethyldeca-(4Z,6E)-dienoic acid (Hdda). (C) 2018 Published by Elsevier Ltd.

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External Sources

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  2. DOI: 10.1016/j.tetlet.2018.05.033
  3. View record in Web of Science®
  4. WOS: 000436221100009

Library Notes

  1. Fiscal Year: FY2017-2018
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