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Nasal cytokine and chemokine responses in experimental influenza A virus infection: Results of a placebo-controlled trial of intravenous zanamivir treatment

  1. Author:
    Fritz, R. S.
    Hayden, F. G.
    Calfee, D. P.
    Cass, L. M. R.
    Peng, A. W.
    Alvord, W. G.
    Strober, W.
    Straus, S. E.

  2. Author Address

    Straus SE NIAID, Clin Invest Lab, NIH Bldg 10,Room 11N228,10 Ctr Dr Bethesda, MD 20892 USA NIAID, Clin Invest Lab, NIH Bethesda, MD 20892 USA Sci Applicat Int Corp, Frederick Canc Res & Dev Ctr Frederick, MD USA Sci Applicat Int Corp, Data Management Serv Frederick, MD USA Univ Virginia, Sch Med Charlottesville, VA 22908 USA GlaxoWellcome Greenford Middx England GlaxoWellcome Res Triangle Pk, NC USA
    1. Year: 1999
  2. Journal: Journal of Infectious Diseases
    1. 180
    2. 3
    3. Pages: 586-593
  4. Type of Article: Article
  1. Abstract:

    The local immune response to influenza virus infection was characterized by determining cytokine and chemokine levels in serial nasal lavage fluid samples from 15 volunteers experimentally infected with influenza A/Texas136/91 (H1N1), The study was Dart of a randomized double-blind placebo-controlled trial to determine the prophylactic effect of intravenous zanamivir (600 mg 2 x /day for 5 days), a highly selective inhibitor of influenza A and B virus neuraminidases, on the clinical symptoms of influenza infection. Nasal lavage fluid levels of interleukin (IL)-6, tumor necrosis factor-alpha, interferon-gamma, IL-10, monocyte chemotactic protein-1, and macrophage inflammatory protein-1 alpha and -1 beta increased in response to influenza virus infection and correlated statistically with the magnitude and time course of the symptoms. Treatment with zanamivir prevented the infection and abrogated the local cytokine and chemokine responses. These results reveal a complex interplay of cytokines and chemokines in the development of symptoms and resolution of influenza. [References: 27]

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