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Design of a multicompartment hydrogel that facilitates time-resolved delivery of combination therapy and synergized killing of glioblastoma

  1. Author:
    Majumder, Poulami
    Baxa, Ulrich
    Walsh, Scott
    Schneider, Joel

  2. Author Address

    National Cancer Institute, Chemical Biology Laboratory, 376 Boyles St, 21702, Frederick, UNITED STATES., Frederick National Laboratory for Cancer Research, 21702, Frederick, UNITED STATES., National Cancer Institute, Chemical Biology Laboratory, 376 Boyles Street, Fort Detrick, 21702, Frederick, UNITED STATES.,
    1. Year: 2018
    2. Date: Nov 12
    3. Epub Date: 2018 09 21
  2. Journal: Angewandte Chemie (International ed. in English)
    1. 57
    2. 46
    3. Pages: 15040-15044
  4. Type of Article: Article
  5. ISSN: 1433-7851
  1. Abstract:

    There is significant current interest in identifying new combination therapies that synergize to treat disease, and it is becoming increasingly clear that the temporal resolution of their administration greatly impacts efficacy.To facilitate effective delivery, we developed a multicompartment hydrogel material composed of spherical vesicles interlaced within a self-assembled peptide-based network of physically crosslinked fibrils that allows time-resolved independent co-delivery of small molecules. Herein, we demonstrate that this material architecture effectively delivers the EGFR kinase inhibitor erlotinib (ERL) and doxorubicin (DOX, DNA intercalator) in an ERL_DOX sequential manner to synergistically kill glioblastoma, the most aggressive form of brain cancer. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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External Sources

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  2. DOI: 10.1002/anie.201806483
  3. PMID: 30240496
  4. View record in Web of Science®
  5. WOS: 000452396800007

Library Notes

  1. Fiscal Year: FY2017-2018
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