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IFNL4-Delta G Allele Is Associated with an Interferon Signature in Tumors and Survival of African-American Men with Prostate Cancer

  1. Author:
    Tang, Wei
    Wallace, Tiffany A.
    Yi, Ming
    Magi-Galluzzi, Cristina
    Dorsey, Tiffany H.
    Onabajo, Olusegun O.
    Obajemu, Adeola
    Jordan, Symone V.
    Loffredo, Christopher A.
    Stephens, Bob
    Silverman, Robert H.
    Stark, George R.
    Klein, Eric A.
    Prokunina-Olsson, Ludmila
    Ambs, Stefan

  2. Author Address

    NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bldg 37, Bethesda, MD 20892 USA.Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc Res Technol Program, Frederick, MD USA.Cleveland Clin, Dept Pathol, Cleveland, OH 44106 USA.NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Canc Prevent & Control Program, Washington, DC 20007 USA.Cleveland Clin, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44106 USA.Cleveland Clin, Glickman Urol & Kidney Inst, Cleveland, OH 44106 USA.
    1. Year: 2018
    2. Date: Nov 1
  2. Journal: CLINICAL CANCER RESEARCH
  3. AMER ASSOC CANCER RESEARCH,
    1. 24
    2. 21
    3. Pages: 5471-5481
  5. Type of Article: Article
  6. ISSN: 1078-0432
  1. Abstract:

    Purpose: Men of African ancestry experience an excessive prostate cancer mortality that could be related to an aggressive tumor biology. We previously described an immune-inflammation signature in prostate tumors of African-American (AA) patients. Here, we further deconstructed this signature and investigated its relationships with tumor biology, survival, and a common germline variant in the IFN lambda 4 (IFNL4) gene.

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External Sources

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  2. DOI: 10.1158/1078-0432.CCR-18-1060
  3. PMCID: 30012562
  4. View record in Web of Science®
  5. WOS: 000448895100028

Library Notes

  1. Fiscal Year: FY2018-2019
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