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CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors

  1. Author:
    Majzner, Robbie G.
    Theruvath, Johanna L.
    Nellan, Anandani
    Heitzeneder, Sabine
    Cui, Yongzhi
    Mount, Christopher W.
    Rietberg, Skyler P.
    Linde, Miles H.
    Xu, Peng
    Rota, Christopher
    Sotillo, Elena
    Labanieh, Louai
    Lee, Daniel W.
    Orentas, Rimas J.
    Dimitrov, Dimiter S.
    Zhu, Zhongyu
    St Croix,Brad
    Delaidelli, Alberto
    Sekunova, Alla
    Bonvini, Ezio
    Mitra, Siddhartha S.
    Quezado, Martha M.
    Majeti, Ravindra
    Monje, Michelle
    Sorensen, Poul H. B.
    Maris, John M.
    Mackall, Crystal L.

  2. Author Address

    Stanford Univ, Sch Med, Dept Pediat, Palo Alto, CA 94304 USA.Univ Colorado, Dept Pediat, Denver Anschutz Med Ctr, Denver, CO 80202 USA.NCI, Pediat Oncol Branch, Bethesda, MD 20892 USA.Stanford Univ, Sch Med, Dept Neurol, Palo Alto, CA 94304 USA.Stanford Univ, Sch Med, Immunol Grad Program, Palo Alto, CA 94304 USA.Inst Stem Cell Biol & Regenerat Med, Palo Alto, CA USA.Stanford Univ, Sch Med, Dept Bioengn, Palo Alto, CA 94304 USA.Univ Virginia, Div Pediat Hematol Oncol, Dept Pediat, Charlottesville, VA USA.Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA.Univ Pittsburgh, Med Sch, Ctr Antibody Therapeut, Pittsburgh, PA USA.NCI, Canc & Inflammat Program, NIH, Frederick, MD 21701 USA.NCI, Tumor Angiogenesis Unit, MCGP, NIH, Frederick, MD 21701 USA.Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada.British Columbia Canc Agcy, Dept Mol Oncol, Vancouver, BC, Canada.MacroGenics Inc, Rockville, MD USA.Stanford Univ, Sch Med, Dept Neurosurg, Palo Alto, CA 94304 USA.NCI, Lab Pathol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA.Stanford Univ, Sch Med, Stanford Canc Inst, Palo Alto, CA 94304 USA.Univ Penn, Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.Univ Penn, Dept Pediat, Philadelphia, PA 19104 USA.
    1. Year: 2019
    2. Date: APR 15
  2. Journal: CLINICAL CANCER RESEARCH
  3. AMER ASSOC CANCER RESEARCH,
    1. 25
    2. 8
    3. Pages: 2560-2574
  5. Type of Article: Article
  6. ISSN: 1078-0432
  1. Abstract:

    Purpose: Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success in treating relapsed pediatric acute lymphoblastic leukemia, but this has not yet translated to treating solid tumors. This is partially due to a paucity of differentially expressed cell surface molecules on solid tumors that can be safely targeted. Here, we present B7-H3 (CD276) as a putative target for CAR T-cell therapy of pediatric solid tumors, including those arising in the central nervous system.

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External Sources

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  2. DOI: 10.1158/1078-0432.CCR-18-0432
  3. PMID: 30655315
  4. View record in Web of Science®
  5. WOS: 000464654200023

Library Notes

  1. Fiscal Year: FY2018-2019
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