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Development of Neutralizing Antibodies against Zika Virus Based on Its Envelope Protein Structure

  1. Author:
    Yang, Chunpeng
    Gong, Rui
    De Val Alda,Natalia

  2. Author Address

    Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China.Univ Chinese Acad Sci, Beijing 100049, Peoples R China.NCI, Ctr Mol Microscopy, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.Leidos Biomedical Res Inc, Canc Res Technol Program, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA.
    1. Year: 2019
    2. Date: APR
    3. Epub Date: 2019 04 24
  2. Journal: Virologica Sinica
  3. SPRINGER,
    1. 34
    2. 2
    3. Pages: 168-174
  5. Type of Article: Review
  6. ISSN: 1674-0769
  1. Abstract:

    As we know more about Zika virus (ZIKV), as well as its linkage to birth defects (microcephaly) and autoimmune neurological syndromes, we realize the importance of developing an efficient vaccine against it. Zika virus disease has affected many countries and is becoming a major public health concern. To deal with the infection of ZIKV, plenty of experiments have been done on selection of neutralizing antibodies that can target the envelope (E) protein on the surface of the virion. However, the existence of antibody-dependent enhancement (ADE) effect might limit the use of them as therapeutic candidates. In this review, we classify the neutralizing antibodies against ZIKV based on the epitopes and summarize the resolved structural information on antibody/antigen complex from X-ray crystallography and cryo-electron microscopy (cryo-EM), which might be useful for further development of potent neutralizing antibodies and vaccines toward clinical use.

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External Sources

  1. View Full Text
  2. DOI: 10.1007/s12250-019-00093-5
  3. PMID: 31020573
  4. View record in Web of Science®
  5. WOS: 000468118700005

Library Notes

  1. Fiscal Year: FY2018-2019
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