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Report on the 2018 Cancer, Autoimmunity, and Immunology Conference

  1. Author:
    Curran, Colleen S.
    Sommers, Connie L.
    Young,Howard
    Bourcier, Katarzyna
    Mancini, Marie
    Sharon, Elad

  2. Author Address

    NIH, Dept Crit Care Med, Clin Ctr, Bethesda, MD 20892 USA.NCI, ImmunoOncol Branch, Dev Therapeut Program, Div Canc Treatment & Diag,NIH, Rockville, MD 20850 USA.NCI, Canc & Inflammat Program, Ctr Canc Res, NIH, Frederick, MD 21702 USA.NIAID, Div Allergy Immunol & Transplantat, NIH, Rockville, MD 20852 USA.NIAMSD, Syst Autoimmune Dis Biol Program, Div Extramural Res, NIH, Bethesda, MD 20892 USA.NCI, Canc Therapy Evaluat Program, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA.
    1. Year: 2019
    2. Date: May 15
    3. Epub Date: 2019 04 15
  2. Journal: Journal of immunology (Baltimore, Md. : 1950)
  3. AMER ASSOC IMMUNOLOGISTS,
    1. 202
    2. 10
    3. Pages: 2823-2828
  5. Type of Article: Article
  6. ISSN: 0022-1767
  1. Abstract:

    With the increased use of cancer immunotherapy, a number of immune-related adverse events (irAEs) are being identified. These irAEs can be compared with known autoimmune disorders in similar tissues, with important similarities and differences. Understanding the etiology of irAEs may bring to light concepts applicable to immune responses in cancer, autoimmunity, and infectious disease. This immunobiology is especially relevant to cancer patients with preexisting allogeneic transplants or autoimmune disease who are undergoing cancer immunotherapy. To address these facets of cancer immunotherapy, academic leaders from these various disciplines discussed current irAE basic and clinical research, irAE diagnosis and management, and the need for biomarkers and algorithms to identify individuals at risk for irAEs at a conference jointly sponsored by the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of Arthritis and Musculoskeletal and Skin Diseases in Bethesda, MD, on March 22-23, 2018. Mechanisms and models to characterize irAEs, standardize protocols, store biospecimens, and capture and analyze irAE data were also reviewed during the inaugural Cancer, Autoimmunity, and Immunology Conference. This summary highlights cancer immunotherapy- induced irAEs, the challenges ahead, and the opportunities for greater understanding of autoimmune conditions.

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External Sources

  1. View Full Text
  2. DOI: 10.4049/jimmunol.1900264
  3. PMID: 30988117
  4. View record in Web of Science®
  5. WOS: 000466980200001

Library Notes

  1. Fiscal Year: FY2018-2019
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