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Identification of HIV transmitting CD11c(+) human epidermal dendritic cells

  1. Author:
    Bertram, Kirstie M.
    Botting, Rachel A.
    Baharlou, Heeva
    Rhodes, Jake W.
    Rana, Hafsa
    Graham, J. Dinny
    Patrick, Ellis
    Fletcher, James
    Plasto, Toby M.
    Truong, Naomi R.
    Royle, Caroline
    Doyle, Chloe M.
    Tong, Orion
    Nasr, Najla
    Barnouti, Laith
    Kohout, Mark P.
    Brooks, Andrew J.
    Wines, Michael P.
    Haertsch, Peter
    Lim, Jake
    Gosselink, Martijn P.
    Ctercteko, Grahame
    Estes,Jake
    Churchill, Melissa J.
    Cameron, Paul U.
    Hunter, Eric
    Haniffa, Muzlifah A.
    Cunningham, Anthony L.
    Harman, Andrew N.

  2. Author Address

    Westmead Inst Med Res, Ctr Virus Res, 176 Hawkesbury Rd, Westmead, NSW 2145, Australia.Univ Sydney, Sydney, NSW 2006, Australia.Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.Australia Plast Surg, 185-211 Broadway, Sydney, NSW 2007, Australia.Westmead Hosp, Westmead, NSW 2145, Australia.Royal North Shore Hosp, Reserve Rd, St Leonards, NSW 2065, Australia.Concord Repatriat Gen Hosp, Burns Unit, Sydney, NSW 2139, Australia.Dr Jake Lim PLC, Shop 12,Cnr Aird & Marsden St, Parramatta, NSW 2150, Australia.Leidos Biomed Res Inc, AIDS & Canc Virus Program, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA.RMIT Univ, Coll Sci Engn & Hlth, Sch Hlth & Biomed Sci, Melbourne, Vic 3001, Australia.Peter Doherty Inst Infect & Immun, 792 Elizabeth St, Melbourne, Vic 3000, Australia.Emory Vaccine Ctr, 954 Gatewood Rd, Atlanta, GA 30329 USA.Newcastle Hosp NHS Fdn Trust, Royal Victoria Infirm, Dept Dermatol, Newcastle Upon Tyne NE2 4LP, Tyne & Wear, England.
    1. Year: 2019
    2. Date: JUN 21
    3. Epub Date: 2019 06 21
  2. Journal: Nature communications
  3. NATURE PUBLISHING GROUP,
    1. 10
    2. 1
    3. Pages: 2759
  5. Type of Article: Article
  6. Article Number: 2759
  7. ISSN: 2041-1723
  1. Abstract:

    Langerhans cells (LC) are thought to be the only mononuclear phagocyte population in the epidermis where they detect pathogens. Here, we show that CD11c(+) dendritic cells (DCs) are also present. These cells are transcriptionally similar to dermal cDC2 but are more efficient antigen-presenting cells. Compared to LCs, epidermal CD11c(+) DCs are enriched in anogenital tissues where they preferentially interact with HIV, express the higher levels of HIV entry receptor CCR5, support the higher levels of HIV uptake and replication and are more efficient at transmitting the virus to CD4 T cells. Importantly, these findings are observed using both a lab-adapted and transmitted/founder strain of HIV. We also describe a CD33(low) cell population, which is transcriptionally similar to LCs but does not appear to function as antigen-presenting cells or acts as HIV target cells. Our findings reveal that epidermal DCs in anogenital tissues potentially play a key role in sexual transmission of HIV.

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External Sources

  1. View Full Text
  2. DOI: 10.1038/s41467-019-10697-w
  3. PMID: 31227717
  4. View record in Web of Science®
  5. WOS: 000472480800001

Library Notes

  1. Fiscal Year: FY2018-2019
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