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RNA Packaging in HIV

  1. Author:
    Rein,Alan

  2. Author Address

    NCI, HIV Dynam & Replicat Program, Ctr Canc Res, Frederick, MD 21702 USA.
    1. Year: 2019
    2. Date: Aug
    3. Epub Date: 2019 05 10
  2. Journal: Trends in microbiology
  3. ELSEVIER SCI LTD,
    1. 27
    2. 8
    3. Pages: 715-723
  5. Type of Article: Review
  6. ISSN: 0966-842X
  1. Abstract:

    Successful replication of the AIDS retrovirus, HIV, requires that its genomic RNA be packaged in assembling virus particles with high fidelity. However, cellular mRNAs can also be packaged under some conditions. Viral RNA (vRNA) contains a 'packaging signal' (psi) and is packaged as a dimer, with two vRNA monomers joined by a limited number of base pairs. It has two conformers, only one of which is capable of dimerization and packaging. Recent years have seen important progress on the 3D structure of dimeric psi. Gag, the protein that assembles into the virus particle, interacts specifically with psi, but this is obscured under physiological conditions by its high nonspecific affinity for any RNA. New results suggest that vRNA is selected for packaging because psi nucleates assembly more efficiently than other RNAs.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.tim.2019.04.003
  3. PMID: 31085095
  4. PMCID: PMC6625830
  5. View record in Web of Science®
  6. WOS: 000474427700009

Library Notes

  1. Fiscal Year: FY2018-2019
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