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MicroRNA networks regulate the differentiation, expansion and suppression function of myeloid-derived suppressor cells in tumor microenvironment

  1. Author:
    Su, Yanping
    Qiu, Ye
    Qiu, Zhidong
    Qu,Peng

  2. Author Address

    Shangdong First Med Univ, Dept Histol & Embryol, Tai An, Shandong, Peoples R China.Shangdong Acad Med Sci, Tai An, Shandong, Peoples R China.Northeast Normal Univ, Natl Engn Lab Druggable Gene & Prot Screening, Changchun, Jilin, Peoples R China.Changchun Univ Chinese Med, Dept Pharm, Changchun, Jilin, Peoples R China.NCI, NIH, Frederick, MD 21702 USA.
    1. Year: 2019
    2. Epub Date: 2019 07 10
  2. Journal: JOURNAL OF CANCER
  3. IVYSPRING INT PUBL,
    1. 10
    2. 18
    3. Pages: 4350-4356
  5. Type of Article: Review
  6. ISSN: 1837-9664
  1. Abstract:

    Myeloid-derived suppressor cells (MDSCs), one heterogeneous population of immature myeloid cells, have suppressive function on immune response during tumor, inflammation, infection and autoimmune diseases. The molecular mechanism underlying expansion and function of MDSCs is becoming appreciated to manipulate immune response in the diseases. MicroRNA (miRNAs) as one short noncoding RNAs, are involved in regulating cell proliferation, differentiation and maturation. However, it needs to be further studied how miRNAs mediate the development and function of MDSC in association with cancer and other diseases. In the review, we report and discuss recent studies that miRNAs networks regulate the differentiation, expansion and suppression function of MDSCs in tumor microenvironment or other diseases through different signaling pathways. Those studies may provide one novel potential approach for tumor immunotherapy.

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External Sources

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  2. DOI: 10.7150/jca.35205
  3. PMID: 31413755
  4. PMCID: PMC6691713
  5. View record in Web of Science®
  6. WOS: 000477730000022

Library Notes

  1. Fiscal Year: FY2018-2019
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