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Sensitivity of Human Papillomavirus (HPV) Lineage and Sublineage Variant Pseudoviruses to Neutralization by Nonavalent Vaccine Antibodies

  1. Author:
    Godi, Anna
    Kemp,Troy
    Pinto,Ligia
    Beddows, Simon

  2. Author Address

    Virus Reference Department, Public Health England, London, U.K., HPV Serology Laboratory, Frederick National Laboratory for Cancer Research, MD, U.S.A.,
    1. Year: 2019
    2. Date: Dec 15
    3. Epub Date: 2019 08 15
  2. Journal: The Journal of infectious diseases
    1. 220
    2. 12
    3. Pages: 1940-1945
  4. Type of Article: Article
  5. ISSN: 0022-1899
  1. Abstract:

    Natural variants of Human papillomavirus (HPV) are classified into lineages and sublineages based upon whole genome sequence, but the impact of diversity on protein function is unclear. We investigated the susceptibility of 3-8 representative pseudovirus variants of HPV16, HPV18, HPV31, HPV33, HPV45, HPV52 and HPV58 to neutralization by nonavalent vaccine (Gardasil®9) sera. Many variants demonstrated significant differences in neutralization sensitivity from their consensus A/A1 variant, but these were of a low magnitude. HPV52 D and HPV58 C variants exhibited >4-fold reduced sensitivities compared to their consensus A/A1 variant and should be considered distinct serotypes with respect to nonavalent vaccine-induced immunity. © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.

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External Sources

  1. View Full Text
  2. DOI: 10.1093/infdis/jiz401
  3. PMID: 31412122
  4. View record in Web of Science®
  5. WOS: 000496768900010
  6. PII : 5550116

Library Notes

  1. Fiscal Year: FY2018-2019
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