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NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening

  1. Author:
    Thornburg,Chris
    Britt,John
    Evans,Jason
    Akee,Rhone
    Whitt, James A.
    Trinh,Spencer
    Harris,Matthew
    Thompson,Jerell
    Ewing,Teresa
    Shipley,Suzanne
    Grothaus,Paul
    Newman,Dave
    Schneider,Joel
    Grkovic,Tanja
    O'Keefe,Barry
  2. Author Address

    NCI, Nat Prod Support Grp, Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Ft Detrick, MD 21702 USA.NCI, Data Management Serv Inc, Frederick Natl Lab Canc Res, Ft Detrick, MD 21702 USA.NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Ft Detrick, MD 21702 USA.NCI, Chem Biol Lab, Ctr Canc Res, Ft Detrick, MD 21702 USA.NCI, Mol Targets Program, Ctr Canc Res, Ft Detrick, MD 21702 USA.
    1. Year: 2018
    2. Date: Sep 21
  1. Journal: ACS CHEMICAL BIOLOGY
  2. AMER CHEMICAL SOC,
    1. 13
    2. 9
    3. Pages: 2484-2497
  3. Type of Article: Article
  4. ISSN: 1554-8929
  1. Abstract:

    The US National Cancer Institute's (NCI) Natural Product Repository is one of the world's largest, most diverse collections of natural products containing over 230,000 unique extracts derived from plant, marine, and microbial organisms that have been collected from biodiverse regions throughout the world. Importantly, this national resource is available to the research community for the screening of extracts and the isolation of bioactive natural products. However, despite the success of natural products in drug discovery, compatibility issues that make extracts challenging for liquid handling systems, extended timelines that complicate natural product-based drug discovery efforts and the presence of pan-assay interfering compounds have reduced enthusiasm for the high-throughput screening (HTS) of crude natural product extract libraries in targeted assay systems. To address these limitations, the NCI Program for Natural Product Discovery (NPNPD), a newly launched, national program to advance natural product discovery technologies and facilitate the discovery of structurally defined, validated lead molecules ready for translation will create a prefractionated library from over 125,000 natural product extracts with the aim of producing a publicly-accessible, HTS-amenable library of >1,000,000 fractions. This library, representing perhaps the largest accumulation of natural-product based fractions in the world, will be made available free of charge in 384-well plates for screening against all disease states in an effort to reinvigorate natural product-based drug discovery.

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External Sources

  1. DOI: 10.1021/acschembio.8b00389
  2. PMID: 29812901
  3. WOS: 000445713100015

Library Notes

  1. Fiscal Year: FY2017-2018
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