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Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence

  1. Author:
    Ramakrishna, Sneha
    Highfill, Steven L.
    Walsh, Zachary
    Nguyen, Sang M.
    Lei, Haiyan
    Shern, Jack F.
    Qin, Haiying
    Kraft, Ira L.
    Stetler-Stevenson, Maryalice
    Yuan, Constance M.
    Hwang, Jennifer D.
    Feng,Yang
    Zhu, Zhongyu
    Dimitrov, Dimiter
    Shah, Nirali N.
    Fry, Terry J.

  2. Author Address

    NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.NIH, Cell Proc Sect, Dept Transfus Med, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA.Colgate Univ, Hamilton, NY 13346 USA.Univ Colorado Denver, Dept Pediat, Aurora, CO USA.Childrens Hosp Colorado, Aurora, CO USA.NCI, Pathol Lab, Ctr Canc Res, NIH, Bldg 10, Bethesda, MD 20892 USA.NCI, Prot Interact Sect Canc, Canc & Inflammat Program, Ctr Canc Res,NIH, Frederick, MD 21701 USA.Stanford Univ, Stanford, CA 94305 USA.Lentigen Technol Inc, Gaithersburg, MD USA.Univ Pittsburgh, Sch Med, Pittsburgh, PA USA.
    1. Year: 2019
    2. Date: Sep 1
  2. Journal: CLINICAL CANCER RESEARCH
  3. AMER ASSOC CANCER RESEARCH,
    1. 25
    2. 17
    3. Pages: 5329-5341
  5. Type of Article: Article
  6. ISSN: 1078-0432
  1. Abstract:

    Purpose: Chimeric antigen receptor T-cell (CART) therapy targeting CD22 induces remission in 70% of patients with relapsed/refractory acute lymphoblastic leukemia (ALL). However, the majority of post-CD22 CART remissions are short and associated with reduction in CD22 expression. We evaluate the implications of low antigen density on the activity of CD22 CART and propose mechanisms to overcome antigen escape.

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External Sources

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  2. DOI: 10.1158/1078-0432.CCR-18-3784
  3. PMID: 31110075
  4. View record in Web of Science®
  5. WOS: 000484118300018

Library Notes

  1. Fiscal Year: FY2019-2020
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