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Combination of Trabectedin With Oxaliplatinum and 5-Fluorouracil Arrests a Primary Colorectal Cancer in a Patient-derived Orthotopic Xenograft Mouse Model

  1. Author:
    Zhu, Guangwei
    Zhao, Ming
    Han, Qinghong
    Tan, Yuying
    Sun, Y U
    Bouvet, Michael
    Singh,Shree Ram
    Ye, Jianxin
    Hoffman, Robert M

  2. Author Address

    AntiCancer, Inc., San Diego, CA, U.S.A., Department of Surgery, University of California, San Diego, CA, U.S.A., Department of Gastrointestinal Surgery 2 Section, The First Hospital Affiliated to Fujian Medical University, Fuzhou, P.R. China., Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, P.R. China., Basic Research Laboratory, National Cancer Institute, Frederick, MD, U.S.A. all@anticancer.com yejianxinfuyi@126.com singhshr@mail.nih.gov., Department of Gastrointestinal Surgery 2 Section, The First Hospital Affiliated to Fujian Medical University, Fuzhou, P.R. China all@anticancer.com yejianxinfuyi@126.com singhshr@mail.nih.gov., AntiCancer, Inc., San Diego, CA, U.S.A. all@anticancer.com yejianxinfuyi@126.com singhshr@mail.nih.gov.,
    1. Year: 2019
    2. Date: Nov
  2. Journal: Anticancer research
    1. 39
    2. 11
    3. Pages: 5999-6005
  4. Type of Article: Article
  5. ISSN: 0250-7005
  1. Abstract:

    BACKGROUND/AIM: In the present study, we aimed to determine the efficacy of trabectedin (TRAB) combined with oxaliplatinum (OXA)+5-fluorouracil (5-FU) on a colorectal cancer (CRC) patient-derived orthotopic xenograft (PDOX) mouse model. MATERIALS AND METHODS: A patient CRC tumor previously established in nude mice was implanted subcutaneously in transgenic green fluorescence protein (GFP)-expressing nude mice. Harvested tumor fragments were transplanted orthotopically in non-transgenic nude mice. Mice were randomized into three groups: Group 1 (G1), untreated-control; Group 2 (G2), OXA+5-FU; Group 3 (G3), TRAB+OXA+5-FU. Tumor width, length, and mouse body weight were measured twice a week. RESULTS: Both treatment groups inhibited tumor growth compared to the untreated control group. The combination of TRAB, OXA and 5-FU was significantly more efficacious than OXA+5-FU and arrested tumor growth. No significant changes were observed in body-weight in any of the three groups. CONCLUSION: TRAB, OXA and 5-FU combination has clinical potential for this and other CRC patients. Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.21873/anticanres.13805
  3. PMID: 31704825
  4. View record in Web of Science®
  5. WOS: 000496129100017
  6. PII : 39/11/5999

Library Notes

  1. Fiscal Year: FY2019-2020
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