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Flip the coin: IL-7 and IL-7R in health and disease

  1. Author:
    Barata, Joao T.
    Durum,Scott
    Seddon, Benedict

  2. Author Address

    Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, Lisbon, Portugal.NCI, Canc & Inflammat Program, Frederick, MD 21701 USA.UCL, Inst Immun & Transplantat, Div Infect & Immun, London, England.
    1. Year: 2019
    2. Date: Dec
    3. Epub Date: 2019 11 19
  2. Journal: Nature immunology
  3. NATURE PUBLISHING GROUP,
    1. 20
    2. 12
    3. Pages: 1584-1593
  5. Type of Article: Review
  6. ISSN: 1529-2908
  1. Abstract:

    The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell development, as well as differentiation and survival of naive Tcells, and generation and maintenance of memory Tcells. They are also required for innate lymphoid cell (ILC) development and maintenance, and consequently for generation of lymphoid structures and barrier defense. Here we discuss the central role of IL-7 and IL-7R in the lymphoid system and highlight the impact of their deregulation, placing a particular emphasis on their 'dark side' as promoters of cancer development. We also explore therapeutic implications and opportunities associated with either positive or negative modulation of the IL-7-IL-7R signaling axis.

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External Sources

  1. View Full Text
  2. DOI: 10.1038/s41590-019-0479-x
  3. PMID: 31745336
  4. View record in Web of Science®
  5. WOS: 000497949800013

Library Notes

  1. Fiscal Year: FY2019-2020
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