Skip NavigationSkip to Content
Return Return to Search Results

EphA7 is required for otic epithelial homeostasis by modulating Claudin6 in Xenopus

  1. Author:
    Wang, Xiaolei
    Sun,Jian
    Wang, Zhaobao
    Li, Chaocui
    Mao, Bingyu

  2. Author Address

    Medical College, Qingdao University, Qingdao, 266071, China; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China., State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; Cancer and Developmental Biology Laboratory, National Cancer Institute, National Institute of Health, Frederick, MD, 21702, USA., School of Control Science and Engineering, Shandong University, Jinan, 250061, China; Energy-rich Compounds Production by Photosynthetic Carbon Fixation Research Center, College of Life Sciences, Qingdao Agricultural University, Qingdao, 266109, China., State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China. Electronic address: mao@mail.kiz.ac.cn.,
    1. Year: 2020
    2. Date: May 28
    3. Epub Date: 2020 03 25
  2. Journal: Biochemical and biophysical research communications
    1. 526
    2. 2
    3. Pages: 375-380
  4. Type of Article: Article
  5. ISSN: 0006-291X
  1. Abstract:

    Receptor tyrosine kinase EphA7 is specifically expressed in otic region in Xenopus early development. However, its role in otocyst development remains unknown. Knockdown of EphA7 by a specific morpholino oligonucleotide (MO) reduced the size of the otocyst and triggered otic epithelial cell extrusion. Interestingly, EphA7 depletion attenuated the membrane level of the tight junction protein Claudin6 (CLDN6). Utilizing the Cldn6 MO, we further confirmed that CLDN6 attenuation also led to otic epithelial cell extrusion. Our work suggested that EphA7 modulates the otic epithelial homeostasis through stabilizing the CLDN6 membrane level. Copyright © 2020 Elsevier Inc. All rights reserved.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.bbrc.2020.03.099
  3. PMID: 32222280
  4. View record in Web of Science®
  5. WOS: 000530031800015
  6. PII : S0006-291X(20)30590-8

Library Notes

  1. Fiscal Year: FY2019-2020
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel