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Genomic mapping in outbred mice reveals overlap in genetic susceptibility for HZE ion- and gamma-ray-induced tumors

  1. Author:
    Edmondson,Elijah
    Gatti, D. M.
    Ray, F. A.
    Garcia, E. L.
    Fallgren, C. M.
    Kamstock, D. A.
    Weil, M. M.

  2. Author Address

    Frederick Natl Lab Canc Res, Frederick, MD 21702 USA.Colorado State Univ, Ft Collins, CO 80523 USA.Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA.
    1. Year: 2020
    2. Date: Apr
    3. Epub Date: 2020 04 15
  2. Journal: SCIENCE ADVANCES
  3. AMER ASSOC ADVANCEMENT SCIENCE,
    1. 6
    2. 16
    3. Pages: eaax5940
  5. Type of Article: Article
  6. Article Number: eaax5940
  7. ISSN: 2375-2548
  1. Abstract:

    Cancer risk from galactic cosmic radiation exposure is considered a potential "showstopper" for a manned mission to Mars. Calculating the actual risks confronted by spaceflight crews is complicated by our limited understanding of the carcinogenic effects of high-charge, high-energy (HZE) ions, a radiation type for which no human exposure data exist. Using a mouse model of genetic diversity, we find that the histotype spectrum of HZE ion-induced tumors is similar to the spectra of spontaneous and y-ray-induced tumors and that the genomic loci controlling susceptibilities overlap between groups for some tumor types. Where it occurs, this overlap indicates shared tumorigenesis mechanisms regardless of the type of radiation exposure and supports the use of human epidemiological data from y-ray exposures to predict cancer risks from galactic cosmic rays.

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External Sources

  1. View Full Text
  2. DOI: 10.1126/sciadv.aax5940
  3. PMID: 32494593
  4. PMCID: PMC7159905
  5. View record in Web of Science®
  6. WOS: 000528276800005

Library Notes

  1. Fiscal Year: FY2019-2020
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