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Ukrain (TM) a semisynthetic Chelidonium majus alkaloid derivative, acts by inhibition of tubulin polymerization in normal and malignant cell lines

  1. Author:
    Panzer, A.
    Hamel, E.
    Joubert, A. M.
    Bianchi, P. C.
    Seegers, J. C.

  2. Author Address

    Univ Pretoria, Dept Physiol, POB 2034, ZA-0001 Pretoria, South Africa. Univ Pretoria, Dept Physiol, ZA-0001 Pretoria, South Africa. NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program, Screening Technol Branch, Frederick, MD 21702 USA. Univ Witwatersrand, Dept Surg, Flow Cytometry Unit, ZA-2050 Wits, South Africa. Joubert AM Univ Pretoria, Dept Physiol, POB 2034, ZA-0001 Pretoria, South Africa.
    1. Year: 2000
  2. Journal: Cancer Letters
    1. 160
    2. 2
    3. Pages: 149-157
  4. Type of Article: Article
  1. Abstract:

    Ukrain (TM) has been described as a semisynthetic Chelidonium majus alkaloid derivative, which exhibits selective toxicity towards malignant cells only. Its mechanism of action has hitherto been uncertain, We found that Ukrain (TM) inhibits tubulin polymerization, leading to impaired microtubule dynamics. This results in activation of the spindle checkpoint and thus a metaphase block. The effects of Ukrainn (TM) on the growth, cell cycle progression and morphology of two normal, two transformed and two malignant cell lines did not differ. We could thus find no evidence for the selective cytotoxicity previously reported for Ukrain (TM). (C) 2000 Elsevier Science ireland Ltd. All rights reserved.

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