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Animal models for COVID-19

  1. Author:
    Munoz-Fontela, Cesar
    Dowling, William E.
    Funnell, Simon G. P.
    Gsell, Pierre-S.
    Riveros-Balta, A. Ximena
    Albrecht, Randy A.
    Andersen, Hanne
    Baric, Ralph S.
    Carroll, Miles W.
    Cavaleri, Marco
    Qin, Chuan
    Crozier,Ian
    Dallmeier, Kai
    de Waal, Leon
    de Wit, Emmie
    Delang, Leen
    Dohm, Erik
    Duprex, W. Paul
    Falzarano, Darryl
    Finch, Courtney L.
    Frieman, Matthew B.
    Graham, Barney S.
    Gralinski, Lisa E.
    Guilfoyle, Kate
    Haagmans, Bart L.
    Hamilton, Geraldine A.
    Hartman, Amy L.
    Herfst, Sander
    Kaptein, Suzanne J. F.
    Klimstra, William B.
    Knezevic, Ivana
    Krause, Philip R.
    Kuhn, Jens H.
    Le Grand, Roger
    Lewis, Mark G.
    Liu, Wen-Chun
    Maisonnasse, Pauline
    McElroy, Anita K.
    Munster, Vincent
    Oreshkova, Nadia
    Rasmussen, Angela L.
    Rocha-Pereira, Joana
    Rockx, Barry
    Rodriguez, Estefania
    Rogers, Thomas F.
    Salguero, Francisco J.
    Schotsaert, Michael
    Stittelaar, Koert J.
    Jan Thibaut, Hendrik
    Tseng, Chien-Te
    Vergara-Alert, Julia
    Beer, Martin
    Brasel, Trevor
    Chan, Jasper F. W.
    Garcia-Sastre, Adolfo
    Neyts, Johan
    Perlman, Stanley
    Reed, Douglas S.
    Richt, Juergen A.
    Roy, Chad J.
    Segales, Joaquim
    Vasan, Seshadri S.
    Henao-Restrepo, Ana Maria
    Barouch, Dan H.

  2. Author Address

    Bernhard Nocht Inst Trop Med, Hamburg, Germany.German Ctr Infect Res DZIF, Partner Site Hamburg Lubeck Borstel Riems, Hamburg, Germany.Ctr Epidem Preparedness Innovat CEPI, Washington, DC USA.Publ Hlth England, Natl Infect Serv, Salisbury, Wilts, England.WHO, Geneva, Switzerland.Icahn Sch Med Mt Sinai, Dept Microbiol, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA.Bioqual Inc, Rockville, MD USA.Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27515 USA.European Med Agcy, Amsterdam, Netherlands.Chinese Acad Med Sci & Peking Union Med Coll, Inst Lab Anim Sci, Beijing, Peoples R China.Frederick Natl Lab Canc Res, Clin Monitoring Res Program Directorate, Frederick, MD USA.Katholieke Univ Leuven, Rega Inst, Lab Virol & Chemotherapy, Dept Microbiol Immunol & Transplantat, Leuven, Belgium.Viroclin Xplore, Schaijk, Netherlands.NIAID, Lab Virol, NIH, Hamilton, MT USA.Univ Alabama Birmingham, Anim Resources Program, Birmingham, AL USA.Univ Pittsburgh, Dept Microbiol & Mol Genet, Ctr Vaccine Res, Pittsburgh, PA USA.Univ Saskatchewan, VIDO Intervac, Saskatoon, SK, Canada.NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA.Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA.NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.Erasmus MC, Dept Virosci, Rotterdam, Netherlands.Emulate Inc, Boston, MA USA.Univ Pittsburgh, Dept Immunol, Ctr Vaccine Res, Pittsburgh, PA USA.US FDA, Ctr Biol Evaluat & Res, Silver Spring, MD USA.Univ Paris Saclay, Ctr Immunol Viral Autoimmune Hematol & Bacterial, INSERM, CEA, Paris, France.Univ Pittsburgh, Sch Med, Div Pediat Infect Dis, Ctr Vaccine Res, Pittsburgh, PA USA.Wageningen Univ & Res, Wageningen Biovet Res WBVR, Lelystad, Netherlands.Columbia Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY USA.Univ Calif San Diego, Div Infect Dis, San Diego, CA 92103 USA.Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA.Campus Univ Autonoma Barcelona, Ctr Recerca Sanitat Anim CReSA, IRTA UAB, Bellaterra, Spain.Friedrich Loeffler Inst, Inst Diagnost Virol, Greifswald, Germany.Univ Hong Kong, Li Ka Shing Fac Med, Dept Microbiol, Carol Yu Ctr Infect, Hong Kong, Peoples R China.Univ Iowa, Dept Microbiol & Immunol, Iowa City, IA USA.Kansas State Univ, Coll Vet Med, Manhattan, KS 66506 USA.Tulane Natl Primate Res Ctr, Covington, LA USA.UAB, Fac Vet, Dept Sanitat & Anat Anim, Bellaterra, Spain.CSIRO, Australian Ctr Dis Preparedness, Geelong, Vic, Australia.Univ York, Dept Hlth Sci, York, N Yorkshire, England.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02115 USA.
    1. Year: 2020
    2. Date: OCT 22
    3. Epub Date: 2020 09 23
  2. Journal: Nature
  3. NATURE RESEARCH,
    1. 586
    2. 7830
    3. Pages: 509-515
  5. Type of Article: Review
  6. ISSN: 0028-0836
  1. Abstract:

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19. The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.

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External Sources

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  2. DOI: 10.1038/s41586-020-2787-6
  3. PMID: 32967005
  4. View record in Web of Science®
  5. WOS: 000580645800024

Library Notes

  1. Fiscal Year: FY2020-2021
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