Skip NavigationSkip to Content
Return Return to Search Results

Use of COMPARE analysis to discover functional analogues of bleomycin

  1. Author:
    Deng, J. Z.
    Newman, D. J.
    Hecht, S. M.

  2. Author Address

    Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA. Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA. Univ Virginia, Dept Biol, Charlottesville, VA 22901 USA. NCI, Frederick Canc Res & Dev Ctr, Nat Prod Branch, Frederick, MD 21702 USA.
    1. Year: 2000
  2. Journal: Journal of Natural Products
    1. 63
    2. 9
    3. Pages: 1269-1272
  4. Type of Article: Article
  1. Abstract:

    Bleomycin was used as the reference compound in a COMPARE analysis to identify extracts in the National Cancer Institute's Natural Products Repository exhibiting cytotoxicity profiles similar to this antitumor agent. One of the extracts so identified was a CH2Cl2-methanol extract prepared from Gymnosporia trigyna, which effected relaxation of supercoiled pSP64 DNA in the presence of Cu2+. Bioassay-guided fractionation using DNA strand-scission activity as an end point resulted in the isolation of four active principles. These were identified as syringaldehyde (1), (-)-syringaresinol (2), (+)-catechin (3), and (+)-epicatechin (4). Compounds 1 and 2 represent a new type of DNA strand-scission agent.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel