Skip NavigationSkip to Content
Return Return to Search Results

Exploring role of 5hmC as potential marker of chemoresistance

  1. Author:
    Kharat,Suhas
    Sharan,Shyam

  2. Author Address

    NCI, Mouse Canc Genet Program, Ctr Canc Res, NIH, Frederick, MD 21702 USA.
    1. Year: 2020
    2. Date: Oct 22
    3. Epub Date: 2020 10 22
  2. Journal: MOLECULAR & CELLULAR ONCOLOGY
  3. TAYLOR & FRANCIS INC,
    1. 7
    2. 6
    3. Pages: 1827904
  5. Type of Article: Article
  6. Article Number: 1827904
  7. ISSN: 2372-3556
  1. Abstract:

    Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresistance mechanisms are unknown. Our recent findings shed light on one such unknown mechanism. We identified a novel role for 5-hydroxymethycytosine (5hmC), an epigenetic mark on the DNA, in maintaining the integrity of stalled replication forks and its impact on genomic stability and chemoresistance. © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1080/23723556.2020.1827904
  3. PMID: 33235920
  4. PMCID: PMC7671001
  5. View record in Web of Science®
  6. WOS: 000587349800001

Library Notes

  1. Fiscal Year: FY2020-2021
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel