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Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans

  1. Author:
    Roome, R Brian
    Bourojeni, Farin B
    Mona, Bishakha
    Rastegar-Pouyani, Shima
    Blain, Raphael
    Dumouchel, Annie
    Salesse, Charleen
    Thompson, W Scott
    Brookbank, Megan
    Gitton, Yorick
    Tessarollo,Lino
    Goulding, Martyn
    Johnson, Jane E
    Kmita, Marie
    Chédotal, Alain
    Kania, Artur

  2. Author Address

    Institut de Recherches Cliniques de Montr 233;al (IRCM), Montr 233;al, QC H2W 1R7, Canada; Integrated Program in Neuroscience, McGill University, Montr 233;al, QC H3A 2B4, Canada., Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Sorbonne Universit 233;, INSERM, CNRS, Institut de la Vision, Paris 75012, France., Institut de Recherches Cliniques de Montr 233;al (IRCM), Montr 233;al, QC H2W 1R7, Canada., Neural Development Section, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD 21702, USA., Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Institut de Recherches Cliniques de Montr 233;al (IRCM), Montr 233;al, QC H2W 1R7, Canada; Division of Experimental Medicine, McGill University, Montr 233;al, QC H3A 2B2, Canada., Institut de Recherches Cliniques de Montr 233;al (IRCM), Montr 233;al, QC H2W 1R7, Canada; Integrated Program in Neuroscience, McGill University, Montr 233;al, QC H3A 2B4, Canada; Department of Anatomy and Cell Biology, McGill University, Montr 233;al, QC H3A 0C7, Canada; Division of Experimental Medicine, McGill University, Montr 233;al, QC H3A 2B2, Canada. Electronic address: artur.kania@ircm.qc.ca.,
    1. Year: 2020
    2. Date: Nov 24
  2. Journal: Cell reports
    1. 33
    2. 8
    3. Pages: 108425
  4. Type of Article: Article
  5. Article Number: 108425
  6. ISSN: 2211-1247
  1. Abstract:

    Anterolateral system neurons relay pain, itch, and temperature information from the spinal cord to pain-related brain regions, but the differentiation of these neurons and their specific contribution to pain perception remain poorly defined. Here, we show that most mouse spinal neurons that embryonically express the autonomic-system-associated Paired-like homeobox 2A (Phox2a) transcription factor innervate nociceptive brain targets, including the parabrachial nucleus and the thalamus. We define the Phox2a anterolateral system neuron birth order, migration, and differentiation and uncover an essential role for Phox2a in the development of relay of nociceptive signals from the spinal cord to the brain. Finally, we also demonstrate that the molecular identity of Phox2a neurons is conserved in the human fetal spinal cord, arguing that the developmental expression of Phox2a is a prominent feature of anterolateral system neurons. Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.celrep.2020.108425
  3. PMID: 33238113
  4. View record in Web of Science®
  5. WOS: 000593108100014
  6. PII : S2211-1247(20)31414-5

Library Notes

  1. Fiscal Year: FY2020-2021
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