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Low-Intensity Pulsed Ultrasound Suppresses Synovial Macrophage Infiltration and Inflammation in Injured Knees in Rats

  1. Author:
    Feltham, Tyler
    Paudel Kattel,Sharada
    Lobao, Mario
    Schon, Lew
    Zhang, Zijun

  2. Author Address

    Philadelphia College of Osteopathic Medicine-Georgia, Suwanee, Georgia, USA., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA., Columbia Medical Center, Columbia University, New York, New York, USA., Institute for Foot & Ankle Reconstruction, Mercy Medical Center, Baltimore, Maryland, USA., Center for Orthopaedic Innovation, Mercy Medical Center, Baltimore, Maryland, USA. Electronic address: zzhang@mdmercy.com.,
    1. Year: 2021
    2. Date: Jan 07
    3. Epub Date: 2021 01 07
  2. Journal: Ultrasound in medicine & biology
  4. Type of Article: Article
  5. Article Number: S0301-5629(20)30575-5
  1. Abstract:

    This study was designed to investigate how low-intensity pulsed ultrasound (LIPUS) suppresses traumatic joint inflammation and thereafter affects the progression of posttraumatic osteoarthritis. Intra-articular fracture (IAF) was created in the right knee of rats. LIPUS was applied to the knees with IAFs for 20 min/d for 2 wk-LIPUS(+) group. The study controls included rats that underwent sham surgery but no LIPUS treatment (control group) or underwent IAF surgery without LIPUS treatment-LIPUS(-) group. By histology, at 4 wk, leukocyte infiltration in the synovium was reduced in the LIPUS(+) group. Furthermore, LIPUS treatment reduced CD68+ macrophages in the synovium and limited their distribution mostly in the subintimal synovium. Measured with enzyme-linked immunosorbent assay, interleukin-1ß (IL-1ß) in the joint fluid of the LIPUS(+) group was reduced to about one-third that in the LIPUS(-) group. By reducing synovial macrophages and lowering IL-1ß in the joint fluid, LIPUS is potentially therapeutic for posttraumatic osteoarthritis. Copyright © 2020 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.ultrasmedbio.2020.12.019
  3. PMID: 33423862
  4. PII : S0301-5629(20)30575-5

Library Notes

  1. Fiscal Year: FY2020-2021
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