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Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs

  1. Author:
    LeBlanc, Amy K.
    Mazcko, Christina N.
    Cherukuri, Aswini
    Berger,Erika
    Kisseberth, William C.
    Brown, Megan E.
    Lana, Susan E.
    Weishaar, Kristen
    Flesner, Brian K.
    Bryan, Jeffrey N.
    Vail, David M.
    Burton, Jenna H.
    Willcox, Jennifer L.
    Mutsaers, Anthony J.
    Woods, J. Paul
    Northrup, Nicole C.
    Saba, Corey
    Curran, Kaitlin M.
    Leeper, Haley
    Wilson-Robles, Heather
    Wustefeld-Janssens, Brandan G.
    Lindley, Stephanie
    Smith, Annette N.
    Dervisis, Nikolaos
    Klahn, Shawna
    Higginbotham, Mary Lynn
    Wouda, Raelene M.
    Krick, Erika
    Mahoney, Jennifer A.
    London, Cheryl A.
    Barber, Lisa G.
    Balkman, Cheryl E.
    McCleary-Wheeler, Angela L.
    Suter, Steven E.
    Martin, Olya
    Borgatti, Antonella
    Burgess, Kristine
    Childress, Michael O.
    Fidel, Janean L.
    Allstadt, Sara D.
    Gustafson, Daniel L.
    Selmic, Laura E.
    Khanna, Chand
    Fan, Timothy M.

  2. Author Address

    NCI, Comparat Oncol Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.NCI, Frederick Natl Lab Canc Res Comparat Oncol Progra, NIH, Bethesda, MD 20892 USA.Ohio State Univ, Coll Vet Med, Dept Vet Clin Sci, Columbus, OH 43210 USA.Colorado State Univ, Coll Vet Med & Biomed Sci, Flint Anim Canc Ctr, Ft Collins, CO 80523 USA.Univ Missouri, Coll Vet Med, Dept Vet Med & Surg, Columbia, MO 65211 USA.Univ Wisconsin, Sch Vet Med, Dept Med Sci, Madison, WI 53706 USA.Univ Calif Davis, Sch Vet Med, Dept Surg & Radiol Sci, Davis, CA 95616 USA.Univ Guelph, Ontario Vet Coll, Dept Clin Studies, Guelph, ON, Canada.Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg, Athens, GA USA.Oregon State Univ, Carlson Coll Vet Med, Dept Clin Sci, Corvallis, OR 97331 USA.Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Small Anim Clin Sci, College Stn, TX USA.Auburn Univ, Coll Vet Med, Wilford & Kate Bailey Small Anim Teaching Hosp, Dept Clin Sci, Auburn, AL 36849 USA.Virginia Maryland Coll Vet Med, Dept Small Anim Clin Sci, Blacksburg, VA USA.Virginia Tech, ICATS Ctr Engn Hlth, Kelly Hall, Blacksburg, VA USA.Virginia Tech, Carilion Sch Med, Dept Internal Med, Roanoke, VA USA.Kansas State Univ, Coll Vet Med, Dept Clin Sci, Manhattan, KS 66506 USA.Univ Penn, Ryan Vet Hosp, Philadelphia, PA 19104 USA.Tufts Univ, Cummings Sch Vet Med, Dept Clin Sci, North Grafton, MA USA.Cornell Univ, Coll Vet Med, Dept Clin Sci, Ithaca, NY 14853 USA.North Carolina State Univ, Coll Vet Med, Dept Clin Sci, Raleigh, NC USA.Univ Tennessee, Coll Vet Med, Dept Small Anim Clin Sci, Knoxville, TN USA.Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN 55108 USA.Purdue Univ, Coll Vet Med, Dept Vet Clin Sci, W Lafayette, IN 47907 USA.Washington State Univ, Coll Vet Med, Dept Vet Clin Sci, Pullman, WA 99164 USA.Ethos Vet Hlth, Woburn, MA USA.Ethos Discovery, San Diego, CA USA.Univ Illinois, Coll Vet Med, Dept Vet Clin Med, Urbana, IL USA.Univ Illinois, Canc Ctr Illinois, Urbana, IL USA.
    1. Year: 2021
    2. Date: Jun 1
    3. Epub Date: 2021 Mar 22
  2. Journal: CLINICAL CANCER RESEARCH
  3. AMER ASSOC CANCER RESEARCH,
    1. 27
    2. Pages: 3005-3016
  5. Type of Article: Article
  6. ISSN: 1078-0432
  1. Abstract:

    Purpose: The mTOR pathway has been identified as a key nutrient signaling hub that participates in metastatic progression of high-grade osteosarcoma. Inhibition of mTOR signaling is biologically achievable with sirolimus, and might slow the outgrowth of distant metastases. In this study, pet dogs with appendicular osteosarcoma were leveraged as high-value biologic models for pediatric osteosarcoma, to assess mTOR inhibition as a therapeutic strategy for attenuating metastatic disease progression.

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External Sources

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  2. DOI: 10.1158/1078-0432.CCR-21-0315
  3. PMID: 33753454
  4. PMCID: PMC8172450
  5. View record in Web of Science®
  6. WOS: 000657419800008

Library Notes

  1. Fiscal Year: FY2020-2021
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