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The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models

  1. Author:
    Kendsersky, Nathan M.
    Lindsay, Jarrett
    Kolb, E. Anders
    Smith, Malcolm A.
    Teicher, Beverly A.
    Erickson, Stephen W.
    Earley, Eric J.
    Mosse, Yael P.
    Martinez, Daniel
    Pogoriler, Jennifer
    Krytska, Kateryna
    Patel, Khushbu
    Groff, David
    Tsang, Matthew
    Ghilu, Samson
    Wang, Yifei
    Seaman,Steven
    Feng,Yang
    St Croix,Brad
    Gorlick, Richard
    Kurmasheva, Raushan
    Houghton, Peter J.
    Maris, John M.

  2. Author Address

    Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA.Childrens Hosp Philadelphia, Ctr Childhood Canc Res, Philadelphia, PA 19104 USA.Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.Alfred I DuPont Hosp Children, Wilmington, DE USA.NCI, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA.RTI Int, Res Triangle Pk, NC USA.Childrens Hosp Philadelphia, Div Anat Pathol, Philadelphia, PA 19104 USA.Childrens Hosp Philadelphia, Dept Biomed & Hlth Informat, Philadelphia, PA 19104 USA.Univ Texas Hlth Sci Ctr San Antonio, Greehey Childrens Canc Res Inst, San Antonio, TX 78229 USA.Univ Texas MD Anderson Canc Ctr, Childrens Canc Hosp, Dept Pediat, Houston, TX 77030 USA.NCI, Tumor Angiogenesis Unit, Mouse Canc Genet Program MCGP, Frederick, MD 21701 USA.
    1. Year: 2021
    2. Date: May 15
  2. Journal: CLINICAL CANCER RESEARCH
  3. AMER ASSOC CANCER RESEARCH,
    1. 27
    2. 10
    3. Pages: 2938-2946
  5. Type of Article: Article
  6. ISSN: 1078-0432
  1. Abstract:

    Purpose: Patients with relapsed pediatric solid malignancies have few therapeutic options, and many of these patients die of their disease. B7-H3 is an immune checkpoint protein encoded by the CD276 gene that is overexpressed in many pediatric cancers. Here, we investigate the activity of the B7-H3-targeting antibody-drug conjugate (ADC) m276-SL-PBD in pediatric solid malignancy patient-derived (PDX) and cell line-derived xenograft (CDX) models.

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External Sources

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  2. DOI: 10.1158/1078-0432.CCR-20-4221
  3. View record in Web of Science®
  4. WOS: 000651778900030

Library Notes

  1. Fiscal Year: FY2020-2021
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