Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox

Author:

Johnson, Reed F

Keith, Lauren A

Cooper, Timothy K

Yellayi, Srikanth

Josleyn, Nicole M

Janosko, Krisztina B

Pettitt, James D

Thomasson, David

Hagen, Katie R

Gross, Robin

Bernbaum, John G

Douglas, Debbie

Solomon,Jeffrey

Martinez, Mark

Cooper, Kurt

St Claire, Marisa

Ragland, Danny R

Jahrling, Peter B

Kuhn, Jens H [ORCID]

Arai, Andrew E
Author Address

Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA., Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA., Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA., Advanced Cardiovascular Imaging Group, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.,

Abstract:

Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial hemorrhages. Previous experiments have demonstrated that intravenous (IV) cowpox virus (CPXV) exposure of macaques mimics human hemorrhagic smallpox. The goal of this experiment was to further understand the onset, nature, and severity of cardiac pathology and how it may contribute to disease. The findings support an acute late-stage myocarditis with lymphohistiocytic infiltrates in the CPXV model of hemorrhagic smallpox.

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Author Address