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Restricting expression prolongs expression of foreign genes introduced into animals by retroviruses

  1. Author:
    Pinto, V. B.
    Prasad, S.
    Yewdell, J.
    Bennink, J.
    Hughes, S. H.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, POB B, Bldg 539, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Frederick, MD 21702 USA. NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA.
    1. Year: 2000
  2. Journal: Journal of Virology
    1. 74
    2. 21
    3. Pages: 10202-10206
  4. Type of Article: Article
  1. Abstract:

    If foreign genes are ubiquitously expressed in mice using a viral vector, expression is abrogated by CD8(+) cells in 2 to 4 weeks. However, if the expression of the genes is confined to skeletal muscle cells, the CD8(+) T-cell response is much weaker and expression is maintained for more than 6 weeks. These data show that restricting the expression of foreign genes to skeletal muscle cells and presumably to other cells that are inefficient at antigen presentation can prolong the expression of a foreign gene product.

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