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A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

  1. Author:
    Luo, Yang
    Kanai, Masahiro
    Choi, Wanson
    Li, Xinyi
    Sakaue, Saori
    Yamamoto, Kenichi
    Ogawa, Kotaro
    Gutierrez-Arcelus, Maria
    Gregersen, Peter K.
    Stuart, Philip E.
    Elder, James T.
    Forer, Lukas
    Schoenherr, Sebastian
    Fuchsberger, Christian
    Smith, Albert V.
    Fellay, Jacques
    Carrington,Mary
    Haas, David W.
    Guo, Xiuqing
    Palmer, Nicholette D.
    Chen, Yii-Der Ida
    Rotter, Jerome I.
    Taylor, Kent D.
    Rich, Stephen S.
    Correa, Adolfo
    Wilson, James G.
    Kathiresan, Sekar
    Cho, Michael H.
    Metspalu, Andres
    Esko, Tonu
    Okada, Yukinori
    Han, Buhm
    McLaren, Paul J.
    Raychaudhuri, Soumya

  2. Author Address

    Harvard Med Sch, Brigham & Womens Hosp, Cter Data Sci, Boston, MA 02115 USA.Harvard Med Sch, Brigham & Womens Hosp, Div Rheumatol Immunol & Immun, Boston, MA 02115 USA.Harvard Med Sch, Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA.Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA USA.Broad Inst Harvard & MIT, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA.Osaka Univ, Grad Sch Med, Dept Stat Genet, Suita, Osaka, Japan.Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea.Univ Chicago, Comm Genet Gen & Syst Biol, Chicago, IL 60637 USA.Osaka Univ, Grad Sch Med, Dept Pediat, Osaka, Japan.Osaka Univ, Dept Neurol, Grad Sch Med, Osaka, Japan.North Short LIJ Hlth Syst, Feinstein Inst Med Res, Robert S Boas Ctr Genom & Human Genet, Manhasset, NY USA.Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA.Ann Arbor Vet Affairs Hosp, Ann Arbor, MI USA.Med Univ Innsbruck, Inst Genet Epidmiol, Dept Genet & Pharmacol, Innsbruck, Austria.Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA.Univ Michigan, Ctr Stat Genet, Sch Publ Hlth, Ann Arbor, MI 48109 USA.Eurac Res, Inst BioMed, Bolzano, Italy.Lausanne Univ Hosp, Precis Med Unit, Lausanne, Switzerland.Univ Lausanne, Lausanne, Switzerland.Ecole Polytech Fed Lausanne, Sch Life Sciences, Lausanne, Switzerland.Natl Canc Inst, Basic Sci Program, Frederick Natl Lab Canc Res, Frederick, MD USA.MIT & Harvaard, Ragon Inst MGH, Boston, MA USA.Vanderbilt Univ, Med Ctr, Nashville, TN USA.Meharry Med Coll, Nashville, TN USA.UCLA Med Ctr, Inst Translat Gen & Populat Sci, Lundquist Inst BioMed Innovat Harbor, Dept Pediat, Torrance, CA USA.Wake Forest Sch Med, Dept Biochem, Winston Salem, NC USA.Univ Virginia, Ctr Publ Hlth Gen, Sch Med, Charlottesville, VA USA.Univ Mississippi, Med, Med Ctr, Jackson, MS USA.Univ Mississippi, Med Ctr, Physiol & Biophys, Jackson, MS USA.Massachusetts Gen Hosp, Ctr Gen Med, Boston, MA USA.Massachusetts Gen Hosp, Dept Med, Cardiol Div, Boston, MA USA.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA USA.Univ Tartu, Inst Gen, Estonian Genome Ctr, Tartu, Estonia.Osaka Univ, Lab Stat Immunol Immunol Frontier Res Ctr WPI IFR, Suita, Japan.Seoul Natl Univ, Interdisciplinary Program BioEngn, Seoul, South Korea.Publ Hlth Agcy Canada, JC Wilt Infect Dis Res Ctr, Natl Microbiol Labs, Winnipeg, MB, Canada.Univ Manitoba, Dept Med Microbiol & Infect Dis, Winnipeg, MB, Canada.Univ Manchester, Ctr Genet & Genom Versus Arthrit, Manchester, England.
    1. Year: 2021
    2. Date: Oct
    3. Epub Date: 2021 Oct 5
  2. Journal: Nature Genetics
  3. Nature Portfolio
    1. 53
    2. 10
    3. Pages: 1504-1516
  5. Type of Article: Article
  6. ISSN: 1061-4036
  1. Abstract:

    A high-resolution reference panel based on whole-genome sequencing data enables accurate imputation of HLA alleles across diverse populations and fine-mapping of HLA association signals for HIV-1 host response.

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External Sources

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  2. DOI: 10.1038/s41588-021-00935-7
  3. PMID: 34611364
  4. View record in Web of Science®
  5. WOS: 000703962800011

Library Notes

  1. Fiscal Year: FY2021-2022
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